ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma

Ji Hyun Hwang, Jungwoo Lee, Won Young Choi, Min Jung Kim, Jiyeon Lee, Khanh Hoang Bao Chu, Lark Kyun Kim, Young Joon Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Hepatocellular carcinoma is a major health burden, and though various treatments through much research are available, difficulties in early diagnosis and drug resistance to chemotherapy-based treatments render several ineffective. Cancer stem cell model has been used to explain formation of heterogeneous cell population within tumor mass, which is one of the underlying causes of high recurrence rate and acquired chemoresistance, highlighting the importance of CSC identification and understanding the molecular mechanisms of CSC drivers. Extracellular CSCmarkers such as CD133, CD90 and EpCAM have been used successfully in CSC isolation, but studies have indicated that increasingly complex combinations are required for accurate identification. Pseudogene-derived long non-coding RNAs are useful candidates as intracellular CSC markers - factors that regulate pluripotency and self-renewal – given their cancer-specific expression and versatile regulation across several levels. Here, we present the use of microarray data to identify stemness-associated factors in liver cancer, and selection of sole pseudogenederived lncRNA ZNF204P for experimental validation. ZNF204P knockdown impairs cell proliferation and migration/invasion. As the cytosolic ZNF204P shares miRNA binding sites with OCT4 and SOX2, well-known drivers of pluripotency and self-renewal, we propose that ZNF204P promotes tumorigenesis through the miRNA-145-5p/OCT4, SOX2 axis.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalBMB reports
Issue number6
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022. by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


Dive into the research topics of 'ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma'. Together they form a unique fingerprint.

Cite this