Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability

Rijuta Ganesh Saratale; Ganesh Dattatraya Saratale; Gajanan Ghodake; Si Kyung Cho; Avinash Kadam; Gopalakrishnan Kumar; Byong Hun Jeon; Deepak Pant; Amit Bhatnagar; Han Seung Shin

doi:10.1016/j.ijbiomac.2019.01.120

Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability

Rijuta Ganesh Saratale, Ganesh Dattatraya Saratale, Gajanan Ghodake, Si Kyung Cho, Avinash Kadam, Gopalakrishnan Kumar, Byong Hun Jeon, Deepak Pant, Amit Bhatnagar, Han Seung Shin

Department of Civil and Environmental Engineering

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Lignin, is the most abundant, renewable and degradable biopolymer available in the nature. The present study exploited purified lignin from wheat straw as reducing, capping and stabilizing agent for the green synthesis of silver nanoparticles (Li-AgNPs) under optimized conditions. The analytical studies revealed synthesized Li-AgNPs having a face centered cubic crystalline structure, size ranging ~15–20 nm and the biomolecules comprising majorly phenolic, hydroxyl and carboxylic group of lignin coated on the surface of AgNPs. Li-AgNPs showed significant antimicrobial efficacy against human pathogens namely; Staphylococcus aureus and Escherichia coli and also determined their minimum inhibitory and minimum bactericidal concentration (MIC and MBC). Li-AgNPs also displayed substantial antioxidant activity in terms of well-known enzyme marker viz.; ABTS and DPPH free radical scavenging assay relative to commercial AgNPs. In vitro cytotoxicity assay of Li-AgNPs demonstrated dose-dependent toxicity effects in SKOV3 ovarian cancer cell line (LD50; 150 μg/mL) indicative of promising anticancer agent. Further, H₂O₂ sensing ability of stabilized Li-AgNPs exhibited its vital role in determining reactive oxygen species. Synthesis of Li-AgNPs is a cheap green technology and could exhibit its commercial use in biomedical, cosmetic, and pharmaceutical industry.

Original language	English
Pages (from-to)	391-400
Number of pages	10
Journal	International Journal of Biological Macromolecules
Volume	128
DOIs	https://doi.org/10.1016/j.ijbiomac.2019.01.120
Publication status	Published - 2019 May 1

Bibliographical note

Funding Information:
The authors gratefully acknowledge the research support by Dongguk University , South Korea under research fund 2018–2020. Authors are thankful to Dr. So Hyun Moon for her kind help during anticancer studies and Prof. Shrikrishna D. Sartale, Savitribai Phule Pune University, Pune, India for his help for the analytical studies. This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through High Value-added Food Technology Development Program funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)( 118056-2 ) and funded by Korea Environmental Industry & Technology Institute ( A117-00197-0703-0 ).

Publisher Copyright:
© 2019

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Molecular Biology
Economics and Econometrics
Energy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijbiomac.2019.01.120

Cite this

Saratale, R. G., Saratale, G. D., Ghodake, G., Cho, S. K., Kadam, A., Kumar, G., Jeon, B. H., Pant, D., Bhatnagar, A., & Shin, H. S. (2019). Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability. International Journal of Biological Macromolecules, 128, 391-400. https://doi.org/10.1016/j.ijbiomac.2019.01.120

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title = "Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability",

abstract = "Lignin, is the most abundant, renewable and degradable biopolymer available in the nature. The present study exploited purified lignin from wheat straw as reducing, capping and stabilizing agent for the green synthesis of silver nanoparticles (Li-AgNPs) under optimized conditions. The analytical studies revealed synthesized Li-AgNPs having a face centered cubic crystalline structure, size ranging ~15–20 nm and the biomolecules comprising majorly phenolic, hydroxyl and carboxylic group of lignin coated on the surface of AgNPs. Li-AgNPs showed significant antimicrobial efficacy against human pathogens namely; Staphylococcus aureus and Escherichia coli and also determined their minimum inhibitory and minimum bactericidal concentration (MIC and MBC). Li-AgNPs also displayed substantial antioxidant activity in terms of well-known enzyme marker viz.; ABTS and DPPH free radical scavenging assay relative to commercial AgNPs. In vitro cytotoxicity assay of Li-AgNPs demonstrated dose-dependent toxicity effects in SKOV3 ovarian cancer cell line (LD50; 150 μg/mL) indicative of promising anticancer agent. Further, H2O2 sensing ability of stabilized Li-AgNPs exhibited its vital role in determining reactive oxygen species. Synthesis of Li-AgNPs is a cheap green technology and could exhibit its commercial use in biomedical, cosmetic, and pharmaceutical industry.",

author = "Saratale, {Rijuta Ganesh} and Saratale, {Ganesh Dattatraya} and Gajanan Ghodake and Cho, {Si Kyung} and Avinash Kadam and Gopalakrishnan Kumar and Jeon, {Byong Hun} and Deepak Pant and Amit Bhatnagar and Shin, {Han Seung}",

note = "Funding Information: The authors gratefully acknowledge the research support by Dongguk University , South Korea under research fund 2018–2020. Authors are thankful to Dr. So Hyun Moon for her kind help during anticancer studies and Prof. Shrikrishna D. Sartale, Savitribai Phule Pune University, Pune, India for his help for the analytical studies. This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through High Value-added Food Technology Development Program funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)( 118056-2 ) and funded by Korea Environmental Industry & Technology Institute ( A117-00197-0703-0 ). Publisher Copyright: {\textcopyright} 2019",

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Saratale, RG, Saratale, GD, Ghodake, G, Cho, SK, Kadam, A, Kumar, G, Jeon, BH, Pant, D, Bhatnagar, A & Shin, HS 2019, 'Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability', International Journal of Biological Macromolecules, vol. 128, pp. 391-400. https://doi.org/10.1016/j.ijbiomac.2019.01.120

Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability. / Saratale, Rijuta Ganesh; Saratale, Ganesh Dattatraya; Ghodake, Gajanan et al.
In: International Journal of Biological Macromolecules, Vol. 128, 01.05.2019, p. 391-400.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Wheat straw extracted lignin in silver nanoparticles synthesis

T2 - Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability

AU - Saratale, Rijuta Ganesh

AU - Saratale, Ganesh Dattatraya

AU - Ghodake, Gajanan

AU - Cho, Si Kyung

AU - Kadam, Avinash

AU - Kumar, Gopalakrishnan

AU - Jeon, Byong Hun

AU - Pant, Deepak

AU - Bhatnagar, Amit

AU - Shin, Han Seung

N1 - Funding Information: The authors gratefully acknowledge the research support by Dongguk University , South Korea under research fund 2018–2020. Authors are thankful to Dr. So Hyun Moon for her kind help during anticancer studies and Prof. Shrikrishna D. Sartale, Savitribai Phule Pune University, Pune, India for his help for the analytical studies. This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through High Value-added Food Technology Development Program funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)( 118056-2 ) and funded by Korea Environmental Industry & Technology Institute ( A117-00197-0703-0 ). Publisher Copyright: © 2019

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Lignin, is the most abundant, renewable and degradable biopolymer available in the nature. The present study exploited purified lignin from wheat straw as reducing, capping and stabilizing agent for the green synthesis of silver nanoparticles (Li-AgNPs) under optimized conditions. The analytical studies revealed synthesized Li-AgNPs having a face centered cubic crystalline structure, size ranging ~15–20 nm and the biomolecules comprising majorly phenolic, hydroxyl and carboxylic group of lignin coated on the surface of AgNPs. Li-AgNPs showed significant antimicrobial efficacy against human pathogens namely; Staphylococcus aureus and Escherichia coli and also determined their minimum inhibitory and minimum bactericidal concentration (MIC and MBC). Li-AgNPs also displayed substantial antioxidant activity in terms of well-known enzyme marker viz.; ABTS and DPPH free radical scavenging assay relative to commercial AgNPs. In vitro cytotoxicity assay of Li-AgNPs demonstrated dose-dependent toxicity effects in SKOV3 ovarian cancer cell line (LD50; 150 μg/mL) indicative of promising anticancer agent. Further, H2O2 sensing ability of stabilized Li-AgNPs exhibited its vital role in determining reactive oxygen species. Synthesis of Li-AgNPs is a cheap green technology and could exhibit its commercial use in biomedical, cosmetic, and pharmaceutical industry.

AB - Lignin, is the most abundant, renewable and degradable biopolymer available in the nature. The present study exploited purified lignin from wheat straw as reducing, capping and stabilizing agent for the green synthesis of silver nanoparticles (Li-AgNPs) under optimized conditions. The analytical studies revealed synthesized Li-AgNPs having a face centered cubic crystalline structure, size ranging ~15–20 nm and the biomolecules comprising majorly phenolic, hydroxyl and carboxylic group of lignin coated on the surface of AgNPs. Li-AgNPs showed significant antimicrobial efficacy against human pathogens namely; Staphylococcus aureus and Escherichia coli and also determined their minimum inhibitory and minimum bactericidal concentration (MIC and MBC). Li-AgNPs also displayed substantial antioxidant activity in terms of well-known enzyme marker viz.; ABTS and DPPH free radical scavenging assay relative to commercial AgNPs. In vitro cytotoxicity assay of Li-AgNPs demonstrated dose-dependent toxicity effects in SKOV3 ovarian cancer cell line (LD50; 150 μg/mL) indicative of promising anticancer agent. Further, H2O2 sensing ability of stabilized Li-AgNPs exhibited its vital role in determining reactive oxygen species. Synthesis of Li-AgNPs is a cheap green technology and could exhibit its commercial use in biomedical, cosmetic, and pharmaceutical industry.

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SN - 0141-8130

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EP - 400

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

ER -

Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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