Weighted mutual information analysis substantially improves domain-based functional network models

Jung Eun Shim, Insuk Lee

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Motivation: Functional protein-protein interaction (PPI) networks elucidate molecular pathways underlying complex phenotypes, including those of human diseases. Extrapolation of domain-domain interactions (DDIs) from known PPIs is a major domain-based method for inferring functional PPI networks. However, the protein domain is a functional unit of the protein. Therefore, we should be able to effectively infer functional interactions between proteins based on the co-occurrence of domains. Results: Here, we present a method for inferring accurate functional PPIs based on the similarity of domain composition between proteins by weighted mutual information (MI) that assigned different weights to the domains based on their genome-wide frequencies. Weighted MI outperforms other domain-based network inference methods and is highly predictive for pathways as well as phenotypes. A genome-scale human functional network determined by our method reveals numerous communities that are significantly associated with known pathways and diseases. Domain-based functional networks may, therefore, have potential applications in mapping domain-to-pathway or domain-to-phenotype associations.

Original languageEnglish
Pages (from-to)2824-2830
Number of pages7
Issue number18
Publication statusPublished - 2016 Sept 15

Bibliographical note

Publisher Copyright:
© 2016 The Author. Published by Oxford University Press. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics


Dive into the research topics of 'Weighted mutual information analysis substantially improves domain-based functional network models'. Together they form a unique fingerprint.

Cite this