Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko; Mingzhou Chen; Kishan Dholakia

doi:10.1117/12.2274974

Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko, Mingzhou Chen, Kishan Dholakia

Department of Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference
Editors	Yasuhiro Awatsuji, Osamu Matoba, Yoshihisa Aizu, Toyohiko Yatagai
Publisher	SPIE
ISBN (Electronic)	9781510610033
DOIs	https://doi.org/10.1117/12.2274974
Publication status	Published - 2017
Event	3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan Duration: 2017 Apr 19 → 2017 Apr 21

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10251
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	3rd Biomedical Imaging and Sensing Conference
Country/Territory	Japan
City	Yokohama
Period	17/4/19 → 17/4/21

Bibliographical note

Publisher Copyright:
© 2017 SPIE.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.2274974

Cite this

Gusachenko, I., Chen, M., & Dholakia, K. (2017). Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes. In Y. Awatsuji, O. Matoba, Y. Aizu, & T. Yatagai (Eds.), Biomedical Imaging and Sensing Conference Article 1025104 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251). SPIE. https://doi.org/10.1117/12.2274974

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abstract = "Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy.",

author = "Ivan Gusachenko and Mingzhou Chen and Kishan Dholakia",

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language = "English",

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Gusachenko, I, Chen, M & Dholakia, K 2017, Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes. in Y Awatsuji, O Matoba, Y Aizu & T Yatagai (eds), Biomedical Imaging and Sensing Conference., 1025104, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10251, SPIE, 3rd Biomedical Imaging and Sensing Conference, Yokohama, Japan, 17/4/19. https://doi.org/10.1117/12.2274974

Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes. / Gusachenko, Ivan; Chen, Mingzhou; Dholakia, Kishan.
Biomedical Imaging and Sensing Conference. ed. / Yasuhiro Awatsuji; Osamu Matoba; Yoshihisa Aizu; Toyohiko Yatagai. SPIE, 2017. 1025104 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy.

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Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Abstract

Publication series

Conference

Bibliographical note

All Science Journal Classification (ASJC) codes

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