Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience

Suyon Chang; Jin Hur; Dong Jin Im; Young Joo Suh; Yoo Jin Hong; Hye Jeong Lee; Young Jin Kim; Kyunghwa Han; Dae Joon Kim; Chang Young Lee; Ha Young Shin; Byoung Wook Choi

doi:10.1007/s00330-016-4542-9

Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience

Suyon Chang, Jin Hur, Dong Jin Im, Young Joo Suh, Yoo Jin Hong, Hye Jeong Lee, Young Jin Kim, Kyunghwa Han, Dae Joon Kim, Chang Young Lee, Ha Young Shin, Byoung Wook Choi

Department of Radiology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.

Original language	English
Pages (from-to)	1992-2001
Number of pages	10
Journal	European Radiology
Volume	27
Issue number	5
DOIs	https://doi.org/10.1007/s00330-016-4542-9
Publication status	Published - 2017 May 1

Bibliographical note

Funding Information:
The scientific guarantor of this publication is Jin Hur, MD, PhD. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-R1A1A1013152). One of the authors has significant statistical expertise. Dr. Kyunghwa Han (Severance Hospital, Yonsei University College of Medicine) provided statistical advice in this study. Institutional Review Board approval was obtained. Written informed consent was obtained from all patients in this study. Methodology: prospective, diagnostic or prognostic study, performed at one institution.

Publisher Copyright:
© 2016, European Society of Radiology.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1007/s00330-016-4542-9

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title = "Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience",

abstract = "Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.",

author = "Suyon Chang and Jin Hur and Im, {Dong Jin} and Suh, {Young Joo} and Hong, {Yoo Jin} and Lee, {Hye Jeong} and Kim, {Young Jin} and Kyunghwa Han and Kim, {Dae Joon} and Lee, {Chang Young} and Shin, {Ha Young} and Choi, {Byoung Wook}",

note = "Funding Information: The scientific guarantor of this publication is Jin Hur, MD, PhD. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-R1A1A1013152). One of the authors has significant statistical expertise. Dr. Kyunghwa Han (Severance Hospital, Yonsei University College of Medicine) provided statistical advice in this study. Institutional Review Board approval was obtained. Written informed consent was obtained from all patients in this study. Methodology: prospective, diagnostic or prognostic study, performed at one institution. Publisher Copyright: {\textcopyright} 2016, European Society of Radiology.",

year = "2017",

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doi = "10.1007/s00330-016-4542-9",

language = "English",

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T1 - Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours

T2 - an initial experience

AU - Chang, Suyon

AU - Hur, Jin

AU - Im, Dong Jin

AU - Suh, Young Joo

AU - Hong, Yoo Jin

AU - Lee, Hye Jeong

AU - Kim, Young Jin

AU - Han, Kyunghwa

AU - Kim, Dae Joon

AU - Lee, Chang Young

AU - Shin, Ha Young

AU - Choi, Byoung Wook

N1 - Funding Information: The scientific guarantor of this publication is Jin Hur, MD, PhD. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012-R1A1A1013152). One of the authors has significant statistical expertise. Dr. Kyunghwa Han (Severance Hospital, Yonsei University College of Medicine) provided statistical advice in this study. Institutional Review Board approval was obtained. Written informed consent was obtained from all patients in this study. Methodology: prospective, diagnostic or prognostic study, performed at one institution. Publisher Copyright: © 2016, European Society of Radiology.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.

AB - Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas. Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis. Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively). Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning. Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.

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ER -

Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience

Abstract

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