Vitamin D Receptor Expression and its Clinical Significance in Papillary Thyroid Cancer

Min Jhi Kim, Daham Kim, Ja Seung Koo, Ju Hee Lee, Kee Hyun Nam

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the association between vitamin D receptor (an essential component in the vitamin D signaling pathway) and serum vitamin D as well as its clinical significance in papillary thyroid cancer. Methods: This prospective cohort study comprised patients with thyroid tumors who visited our hospital, from 2017 to 2018. The level of vitamin D receptor expression from thyroid tissue was measured in patients with thyroid tumor and evaluated for correlation with serum vitamin D levels and clinicopathologic characteristics of papillary thyroid cancer. Data from 501 patients with papillary thyroid cancer from The Cancer Genome Atlas database were analyzed. Results: Increased vitamin D receptor protein and mRNA expression were observed in papillary thyroid cancer compared to those in normal and benign tissues. Lower vitamin D receptor protein expression was associated with high TNM stage papillary thyroid cancer and low p21 protein expression. Lower relative vitamin D receptor mRNA expression in papillary thyroid cancer was associated with low serum 25-hydroxyvitamin D level. The Cancer Genome Atlas database showed a positive correlation among mRNA expression of vitamin D receptor, CYP24A1, and p21. Conclusions: An association between decreased vitamin D receptor protein expression and advanced stage papillary thyroid cancer, and a correlation between low vitamin D receptor mRNA expression with low serum 25-hydroxyvitamin D level was observed. Low vitamin D receptor expression in papillary thyroid cancer was shown to positively correlate with low serum vitamin D level and disease aggressiveness.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalTechnology in Cancer Research and Treatment
Volume21
DOIs
Publication statusPublished - 2022 Apr

Bibliographical note

Publisher Copyright:
© The Author(s) 2022.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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