Visualization of maturation of the corpus callosum during childhood and adolescence using T2 relaxometry

Eung Y. Kim, Dong Hyun Kim, Eunhye Yoo, Hae Jeong Park, Xavier Golay, Seung Koo Lee, Dong J. Kim, Jinna Kim, Dong I. Kim

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17 Citations (Scopus)


Previous studies have shown that maturation of the white matter in terms of its relative signal intensity changes on MRI is almost complete at 2-3 years of age. We hypothesized that quantitative analysis may show maturation of the white matter during childhood and adolescence. In the present study we performed multi-echo T2 relaxometry in 33 healthy subjects (girls, 15; boys, 18) aged 3-15 years. T2 relaxation times of the genu and splenium were measured. In healthy subjects, the T2 relaxation times were significantly correlated with age in both girls (r = 0.611, p = .016) and boys (r = 0.721, p = .001) in the splenium, but not in the genu (p > .05). To further confirm genu-to-splenium signal intensity ratio changes, a total of 389 brain MRIs were retrospectively selected from the patients who had normal results (189 girls/women, 200 boys/men; age range, 3-20 years). The genu-to-splenium signal intensity ratio was obtained from the T2-weighted images. In patients with normal MRI, the genu-to-splenium signal intensity ratio was significantly decreased with age (p < .001) by 16 years. The T2 relaxation times gradually increase in the splenium during childhood and adolescence, suggestive of maturation.

Original languageEnglish
Pages (from-to)409-414
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Issue number6
Publication statusPublished - 2007 Oct

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV07-0002) (Hae-Jeong Park).

Funding Information:
This work was supported by a faculty research grant of Yonsei University College of Medicine for 2005 (No. 2005-0103), a Yonsei University Research Fund of 2005, and a Schering Radiological Research Fund of the Korean Radiological Society of 2005 (Eung Y. Kim).

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology


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