Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375

Nyung Kim; Mi Jin Sohn; Chang Jin Kim; Ho Jeong Kwon; Won Gon Kim

doi:10.1016/j.bmcl.2012.02.001

Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375

Nyung Kim, Mi Jin Sohn, Chang Jin Kim, Ho Jeong Kwon, Won Gon Kim

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC ₅₀ of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.

Original language	English
Pages (from-to)	2503-2506
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2012.02.001
Publication status	Published - 2012 Apr 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education, Science and Technology (2009-0075824).

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2012.02.001

Cite this

@article{d971a940278946379a6fa38787ab666b,

title = "Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375",

abstract = "New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.",

author = "Nyung Kim and Sohn, {Mi Jin} and Kim, {Chang Jin} and Kwon, {Ho Jeong} and Kim, {Won Gon}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education, Science and Technology (2009-0075824).",

year = "2012",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2012.02.001",

language = "English",

volume = "22",

pages = "2503--2506",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "7",

}

TY - JOUR

T1 - Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375

AU - Kim, Nyung

AU - Sohn, Mi Jin

AU - Kim, Chang Jin

AU - Kwon, Ho Jeong

AU - Kim, Won Gon

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education, Science and Technology (2009-0075824).

PY - 2012/4/1

Y1 - 2012/4/1

N2 - New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.

AB - New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.

UR - http://www.scopus.com/inward/record.url?scp=84862820527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862820527&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2012.02.001

DO - 10.1016/j.bmcl.2012.02.001

M3 - Article

C2 - 22377515

AN - SCOPUS:84862820527

SN - 0960-894X

VL - 22

SP - 2503

EP - 2506

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this