Variations in 18F-FDG uptake in breast cancer depending on PET/CT acquisition position

J. H. Lee, T. J. Jeon, S. G. Ahn, J. Jeong, J. W. Seok, Y. H. Ryu

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1 Citation (Scopus)


Aim To evaluate the variability of quantitative 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) parameters depending on acquisition position in a dual-position protocol for breast cancers. Materials and methods For initial staging work-up, whole-body PET/CT was first acquired in a supine position, and then followed by a regional breast scan in a prone position. The maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) were measured on both acquisition positions. MTV50 and TLG50 were calculated with a threshold set to be 50% of SUVmax, and MTV2.5 and TLG2.5 with a fixed SUV threshold of 2.5. Results The median SUVmax of breast cancers measured on the supine scans was 4.88, and 4.49 on the prone images (p<0.05). MTV and TLG also yielded significantly lower values from supine images. Regarding the tendency for the acquisition position to yield different results, a significant disagreement was observed between SUVmax and MTV50 and between SUVmax and TLG50 (kappa = -0156 and -0.001, respectively), while MTV2.5 and TLG2.5 showed a fair to moderate agreement with SUVmax (kappa = 0.311 and 0.416, respectively). Conclusions SUVmax, MTV, and TLG yielded lower values when acquired in the prone position compared to in the supine position. This observation could be due to the partial volume effect. When using 50% of SUVmax as a threshold, there was a significant discordance between SUVmax and volumetric parameters. Thus, acquisition position may affect quantitative PET/CT parameters and the clinical implications.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalClinical Radiology
Issue number1
Publication statusPublished - 2016 Jan 1

Bibliographical note

Publisher Copyright:
© 2015 The Royal College of Radiologists.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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