Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound

In Hye Chae; Hyeong Ju Kwon; Eun Kyung Kim; Hee Jung Moon; Jung Hyun Yoon; Hye Sun Lee; Jin Young Kwak

doi:10.1016/j.prp.2016.02.014

Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound

In Hye Chae, Hyeong Ju Kwon, Eun Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Hye Sun Lee, Jin Young Kwak

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.

Original language	English
Pages (from-to)	415-420
Number of pages	6
Journal	Pathology Research and Practice
Volume	212
Issue number	5
DOIs	https://doi.org/10.1016/j.prp.2016.02.014
Publication status	Published - 2016 May 1

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education ( 2013R1A1A2058817 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to gratefully and sincerely thank Kyunghee Han, who performed elaborated von Kossa staining in the laboratory of the Department of Pathology, Severance Hospital.

Publisher Copyright:
© 2016 Elsevier GmbH.

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Cell Biology

Access to Document

10.1016/j.prp.2016.02.014

Cite this

@article{3311344694f24590b71f168fedc1c50c,

title = "Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound",

abstract = "Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.",

author = "Chae, {In Hye} and Kwon, {Hyeong Ju} and Kim, {Eun Kyung} and Moon, {Hee Jung} and Yoon, {Jung Hyun} and Lee, {Hye Sun} and Kwak, {Jin Young}",

note = "Funding Information: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education ( 2013R1A1A2058817 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to gratefully and sincerely thank Kyunghee Han, who performed elaborated von Kossa staining in the laboratory of the Department of Pathology, Severance Hospital. Publisher Copyright: {\textcopyright} 2016 Elsevier GmbH.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.prp.2016.02.014",

language = "English",

volume = "212",

pages = "415--420",

journal = "Pathology Research and Practice",

issn = "0344-0338",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "5",

}

TY - JOUR

T1 - Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound

AU - Chae, In Hye

AU - Kwon, Hyeong Ju

AU - Kim, Eun Kyung

AU - Moon, Hee Jung

AU - Yoon, Jung Hyun

AU - Lee, Hye Sun

AU - Kwak, Jin Young

N1 - Funding Information: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education ( 2013R1A1A2058817 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to gratefully and sincerely thank Kyunghee Han, who performed elaborated von Kossa staining in the laboratory of the Department of Pathology, Severance Hospital. Publisher Copyright: © 2016 Elsevier GmbH.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.

AB - Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.

UR - http://www.scopus.com/inward/record.url?scp=84963894020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963894020&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2016.02.014

DO - 10.1016/j.prp.2016.02.014

M3 - Article

C2 - 26916952

AN - SCOPUS:84963894020

SN - 0344-0338

VL - 212

SP - 415

EP - 420

JO - Pathology Research and Practice

JF - Pathology Research and Practice

IS - 5

ER -

Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this