Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound

In Hye Chae, Hyeong Ju Kwon, Eun Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Hye Sun Lee, Jin Young Kwak

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). Materials and methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P = 0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P = 0.021). Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.

Original languageEnglish
Pages (from-to)415-420
Number of pages6
JournalPathology Research and Practice
Issue number5
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education ( 2013R1A1A2058817 ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to gratefully and sincerely thank Kyunghee Han, who performed elaborated von Kossa staining in the laboratory of the Department of Pathology, Severance Hospital.

Publisher Copyright:
© 2016 Elsevier GmbH.

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology


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