Vagus nerve stimulation in intractable childhood epilepsy: A Korean multicenter experience

Jeong You Su, Hoon Chul Kang, Dong Kim Heung, Tae Sung Ko, Deok Soo Kim, Soon Hwang Yong, Suk Kim Dong, Jung Kyo Lee, Keun Park Sang

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


We evaluated the long-term outcome of vagus nerve stimulation (VNS) in 28 children with refractory epilepsy. Of these 28 children, 15 (53.6%) showed a >50% reduction in seizure frequency and 9 (32.1%) had a >75% reduction. When we compared seizure reduction rates according to seizure types (generalized vs. partial) and etiologies (symptomatic vs. cryptogenic), we found no significant differences. In addition, there was no correlation between the length of the stimulation period and treatment effect. The seizure reduction rate, however, tended to be inversely related to the seizure duration before VNS implantation and age at the time of VNS therapy. VNS also improved quality of life in this group of patients, including improved memory in 9 (32.1%), improved mood in 12 (42.9%), improved behavior in 11 (39.3%), improved altertness in 12 (42.9%), improved achievement in 6 (21.4%), and improved verbal skills in 8 (28.6%). Adverse events included hoarseness in 7 patients, dyspnea at sleep in 2 patients, and wound infection in 1 patient, but all were transient and successfully managed by careful follow-up and adjustment of parameters. These results indicate that VNS is a safe and effective alternative therapy for pediatric refractory epilepsy, without significant adverse events.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalJournal of Korean medical science
Issue number3
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • General Medicine


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