Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

Jun Y. Cho; Dae Y. Hwang; Tae S. Kang; Dong H. Shin; Jin H. Hwang; Chae H. Lim; Su H. Lee; Hwa J. Lim; Sae H. Min; Su J. Seo; Youn S. Song; Ki T. Nam; Kyu S. Lee; Jung S. Cho; Yong K. Kim

doi:10.1080/0264041031000140365

Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

Jun Y. Cho, Dae Y. Hwang, Tae S. Kang, Dong H. Shin, Jin H. Hwang, Chae H. Lim, Su H. Lee, Hwa J. Lim, Sae H. Min, Su J. Seo, Youn S. Song, Ki T. Nam, Kyu S. Lee, Jung S. Cho, Yong K. Kim

BioMedical Science Institute

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.

Original language	English
Pages (from-to)	943-951
Number of pages	9
Journal	Journal of Sports Sciences
Volume	21
Issue number	11
DOIs	https://doi.org/10.1080/0264041031000140365
Publication status	Published - 2003 Nov

Bibliographical note

Funding Information:
We thank Sun M. Choi and Mi K. Jang, animal technicians, for directing the animal facility at the Division of Laboratory Animal Resources. This research was supported by grants to Yong K. Kim from the Korean Ministry of Health and Welfare (01-PJ1-963-20500-0129) and the Korea FDA.

All Science Journal Classification (ASJC) codes

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/0264041031000140365

Cite this

Cho, J. Y., Hwang, D. Y., Kang, T. S., Shin, D. H., Hwang, J. H., Lim, C. H., Lee, S. H., Lim, H. J., Min, S. H., Seo, S. J., Song, Y. S., Nam, K. T., Lee, K. S., Cho, J. S., & Kim, Y. K. (2003). Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease. Journal of Sports Sciences, 21(11), 943-951. https://doi.org/10.1080/0264041031000140365

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title = "Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease",

abstract = "In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.",

author = "Cho, {Jun Y.} and Hwang, {Dae Y.} and Kang, {Tae S.} and Shin, {Dong H.} and Hwang, {Jin H.} and Lim, {Chae H.} and Lee, {Su H.} and Lim, {Hwa J.} and Min, {Sae H.} and Seo, {Su J.} and Song, {Youn S.} and Nam, {Ki T.} and Lee, {Kyu S.} and Cho, {Jung S.} and Kim, {Yong K.}",

note = "Funding Information: We thank Sun M. Choi and Mi K. Jang, animal technicians, for directing the animal facility at the Division of Laboratory Animal Resources. This research was supported by grants to Yong K. Kim from the Korean Ministry of Health and Welfare (01-PJ1-963-20500-0129) and the Korea FDA.",

year = "2003",

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doi = "10.1080/0264041031000140365",

language = "English",

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T1 - Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

AU - Cho, Jun Y.

AU - Hwang, Dae Y.

AU - Kang, Tae S.

AU - Shin, Dong H.

AU - Hwang, Jin H.

AU - Lim, Chae H.

AU - Lee, Su H.

AU - Lim, Hwa J.

AU - Min, Sae H.

AU - Seo, Su J.

AU - Song, Youn S.

AU - Nam, Ki T.

AU - Lee, Kyu S.

AU - Cho, Jung S.

AU - Kim, Yong K.

N1 - Funding Information: We thank Sun M. Choi and Mi K. Jang, animal technicians, for directing the animal facility at the Division of Laboratory Animal Resources. This research was supported by grants to Yong K. Kim from the Korean Ministry of Health and Welfare (01-PJ1-963-20500-0129) and the Korea FDA.

PY - 2003/11

Y1 - 2003/11

N2 - In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.

AB - In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.

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Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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