Updates on the ketogenic diet therapy for pediatric epilepsy

Ara Ko, Hye Eun Kwon, Heung Dong Kim

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

The ketogenic diet (KD) is a high-fat, low-carbohydrate diet, in which fat, instead of glucose, acts as a major energy source through the production of ketone bodies. The KD was formally introduced in 1921 to mimic the biochemical changes associated with fasting and gained recognition as a potent treatment for pediatric epilepsy in the mid-1990s. Recent clinical and scientific knowledge supports the use of the KD in drug-resistant epilepsy patients for its anti-seizure efficacy, safety, and tolerability. The KD is also receiving growing attention as a potential treatment option for other neurological disorders. This article will review on the recent updates on the KD, focusing on its mechanisms of action, its alternatives, expansion on its use in terms of age groups and different regions in the world, and future issues.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalBiomedical Journal
Volume45
Issue number1
DOIs
Publication statusPublished - 2022 Feb

Bibliographical note

Publisher Copyright:
© 2021 Chang Gung University

All Science Journal Classification (ASJC) codes

  • General Medicine

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