Update on Preoperative Parathyroid Localization in Primary Hyperparathyroidism

Hye Sun Park, Namki Hong, Jong Ju Jeong, Mijin Yun, Yumie Rhee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Parathyroidectomy is the treatment of choice for primary hyperparathyroidism when the clinical criteria are met. Although bilateral neck exploration is traditionally the standard method for surgery, minimally invasive parathyroidectomy (MIP), or focused parathyroidectomy, has been widely accepted with comparable curative outcomes. For successful MIP, accurate preoperative localization of parathyroid lesions is essential. However, no consensus exists on the optimal approach for localization. Currently, ultrasonography and technetium-99m-sestamibi–single photon emission computed tomography/computed tomography are widely accepted in most cases. However, exact localization cannot always be achieved, especially in cases with multiglandular disease, ectopic glands, recurrent disease, and normocalcemic primary hyperparathyroidism. Therefore, new modalities for preoperative localization have been developed and evaluated. Positron emission tomography/computed tomography and parathyroid venous sampling have demonstrated improvements in sensitivity and accuracy. Both anatomical and functional information can be obtained by combining these methods. As each approach has its advantages and disadvantages, the localization study should be deliberately chosen based on each patient’s clinical profile, costs, radiation exposure, and the availability of experienced experts. In this review, we summarize various methods for the localization of hyperfunctioning parathyroid tissues in primary hyperparathyroidism.

Original languageEnglish
Pages (from-to)744-755
Number of pages12
JournalEndocrinology and Metabolism
Issue number5
Publication statusPublished - 2022 Oct

Bibliographical note

Publisher Copyright:
Copyright © 2022 Korean Endocrine Society.

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Update on Preoperative Parathyroid Localization in Primary Hyperparathyroidism'. Together they form a unique fingerprint.

Cite this