Two cases of pancreatic panniculitis

Several pancreatic diseases have been associated with a characteristic variant of panniculitis, named pancreatic panniculitis. This variant appears in approximately 2 - 3% of all patients with pancreatic diseases. We experienced two cases of panniculitis associated with pancreatic diseases. Two patients presented with erythematous tender subcutaneous nodules on the lower extremities. The serum amylase and lipase levels were significantly elevated. Histopathologic findings showed subcutaneous fat necrosis, ghost cell formation and mixed infiltration of neutrophils at the periphery. The lesions subsided gradually with the correction of the underlying pancreatic diseases.