Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study

Tae Kyeong Lim; Hye Sun Lee; Yong Jae Lee

doi:10.1016/j.diabres.2020.108150

Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study

Tae Kyeong Lim, Hye Sun Lee, Yong Jae Lee

Department of Family Medicine

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Aims: Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. Methods: Among 10,038 participants, a total of 8655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥ 126 mg/dL; a glucose level ≥ 200 mg/dL 2-hours after a 75 g oral glucose tolerance test; an HbA1c ≥ 6.5%; or treatment with anti-diabetic therapy. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. Results: During the 12-year follow-up period, type 2 diabetes developed in 1437 subjects (16.6%, 1437/8655), with incidence rate of 2.8–5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. Conclusions: High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes.

Original language	English
Article number	108150
Journal	Diabetes Research and Clinical Practice
Volume	163
DOIs	https://doi.org/10.1016/j.diabres.2020.108150
Publication status	Published - 2020 May

Bibliographical note

Funding Information:
The authors would like to thank those who participated in the KoGES. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. None. T.K.L. conceptualized and designed the study; collected, analyzed, and interpreted the data; wrote the first draft and revised later drafts of the manuscript. T.K.L. and H.S.L. analyzed and interpreted the data, and performed the statistical analysis. Y.J.L. revised the article. Y.J.L. is the guarantor of this work and, as such, had full access to all of the data in the study and take responsibility for its integrity, and the accuracy of the data analysis. The dataset used in this study (Ansan-Ansung cohort) can be provided after review and evaluation of research plan by the Korea Centers for Disease Control and Prevention (http://www.cdc.go.kr/CDC/eng/main.jsp).

Publisher Copyright:
© 2020 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2020.108150

Cite this

@article{a71d2887648645309ea2bb2867a07954,

title = "Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study",

abstract = "Aims: Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. Methods: Among 10,038 participants, a total of 8655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥ 126 mg/dL; a glucose level ≥ 200 mg/dL 2-hours after a 75 g oral glucose tolerance test; an HbA1c ≥ 6.5%; or treatment with anti-diabetic therapy. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. Results: During the 12-year follow-up period, type 2 diabetes developed in 1437 subjects (16.6%, 1437/8655), with incidence rate of 2.8–5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. Conclusions: High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes.",

author = "Lim, {Tae Kyeong} and Lee, {Hye Sun} and Lee, {Yong Jae}",

note = "Funding Information: The authors would like to thank those who participated in the KoGES. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. None. T.K.L. conceptualized and designed the study; collected, analyzed, and interpreted the data; wrote the first draft and revised later drafts of the manuscript. T.K.L. and H.S.L. analyzed and interpreted the data, and performed the statistical analysis. Y.J.L. revised the article. Y.J.L. is the guarantor of this work and, as such, had full access to all of the data in the study and take responsibility for its integrity, and the accuracy of the data analysis. The dataset used in this study (Ansan-Ansung cohort) can be provided after review and evaluation of research plan by the Korea Centers for Disease Control and Prevention (http://www.cdc.go.kr/CDC/eng/main.jsp). Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = may,

doi = "10.1016/j.diabres.2020.108150",

language = "English",

volume = "163",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study. / Lim, Tae Kyeong; Lee, Hye Sun; Lee, Yong Jae.
In: Diabetes Research and Clinical Practice, Vol. 163, 108150, 05.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults

T2 - A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study

AU - Lim, Tae Kyeong

AU - Lee, Hye Sun

AU - Lee, Yong Jae

N1 - Funding Information: The authors would like to thank those who participated in the KoGES. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. None. T.K.L. conceptualized and designed the study; collected, analyzed, and interpreted the data; wrote the first draft and revised later drafts of the manuscript. T.K.L. and H.S.L. analyzed and interpreted the data, and performed the statistical analysis. Y.J.L. revised the article. Y.J.L. is the guarantor of this work and, as such, had full access to all of the data in the study and take responsibility for its integrity, and the accuracy of the data analysis. The dataset used in this study (Ansan-Ansung cohort) can be provided after review and evaluation of research plan by the Korea Centers for Disease Control and Prevention (http://www.cdc.go.kr/CDC/eng/main.jsp). Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020/5

Y1 - 2020/5

N2 - Aims: Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. Methods: Among 10,038 participants, a total of 8655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥ 126 mg/dL; a glucose level ≥ 200 mg/dL 2-hours after a 75 g oral glucose tolerance test; an HbA1c ≥ 6.5%; or treatment with anti-diabetic therapy. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. Results: During the 12-year follow-up period, type 2 diabetes developed in 1437 subjects (16.6%, 1437/8655), with incidence rate of 2.8–5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. Conclusions: High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes.

AB - Aims: Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. Methods: Among 10,038 participants, a total of 8655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥ 126 mg/dL; a glucose level ≥ 200 mg/dL 2-hours after a 75 g oral glucose tolerance test; an HbA1c ≥ 6.5%; or treatment with anti-diabetic therapy. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. Results: During the 12-year follow-up period, type 2 diabetes developed in 1437 subjects (16.6%, 1437/8655), with incidence rate of 2.8–5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. Conclusions: High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes.

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Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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