Treatment outcomes of sinonasal adenoid cystic carcinoma: 30 cases from a single institution

Sang Yeob Seong, Dong Woo Hyun, Yoo Suk Kim, Hyung Ju Cho, Jeung Gweon Lee, Joo Heon Yoon, Chang Hoon Kim

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25 Citations (Scopus)


Objective To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). Material and methods Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. Results The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. Conclusion Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.

Original languageEnglish
Pages (from-to)e171-e175
JournalJournal of Cranio-Maxillofacial Surgery
Issue number5
Publication statusPublished - 2014 Jul

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology ( 2012R1A1A2042476 ).

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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