Treatment of recurrent hepatocellular carcinoma after liver transplantation

Hye Ryun Kim, Seong Ha Cheon, Sun Young Rha, Soohyeon Lee, Kwang Hyub Han, Chae Yoon Chon, Jong Doo Lee, Jin Sil Sung, Hyun Cheol Chung

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Aim: Liver transplantation (LT) is a curative treatment for localized hepatocellular carcinoma (HCC), but the recurrence rate after LT is about 10-20%, with a dismal prognosis. Little data exist as to the natural history, treatment outcome and optimal treatment of recurrent HCC after LT. We reviewed various treatment modalities given to patients with recurrent HCC after LT. Methods: Among 132 patients who underwent LT for localized HCC, we retrospectively reviewed medical records of 39 of the 132 patients who developed recurrent HCC after LT. We analyzed the clinical outcome of various treatment modalities and treatment-related adverse events. Results: A total of 39 (29%) of the original 132 patients had recurrent HCC, most recurrences (82%) having occurred within 1year after LT and involved extrahepatic lesions. Only seven patients had recurrent disease limited to the liver. The median overall survival from the initial treatment of all relapsed patients was 6.9 months. There were various initial treatment modalities, namely palliative systemic chemotherapy, trans-catheter arterial chemo-embolization/infusion (TACE/I), radiation therapy (RT), surgical resection and no treatment. The median overall survival was 9.5 months for first-line chemotherapy, including those who had prior local therapy, 6.3 months TACE/I and 6.9 months for RT. Conclusion: Various clinical approaches have been used to treat patients with recurrent HCC after LT in a clinical setting. More effective strategies and clinical guidelines for recurrent HCC following LT must be established.

Original languageEnglish
Pages (from-to)258-269
Number of pages12
JournalAsia-Pacific Journal of Clinical Oncology
Issue number3
Publication statusPublished - 2011 Sept

All Science Journal Classification (ASJC) codes

  • Oncology


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