Transparent neural implantable devices: a comprehensive review of challenges and progress

Young Uk Cho; Se Lin Lim; Jung Hoon Hong; Ki Jun Yu

doi:10.1038/s41528-022-00178-4

Transparent neural implantable devices: a comprehensive review of challenges and progress

Young Uk Cho, Se Lin Lim, Jung Hoon Hong, Ki Jun Yu

Department of Electrical and Electronic Engineering

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

Abstract

The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods in a single tool. In conjunction with the integration of electrophysiology and optical modalities, a transparent neural interface alleviates challenges of conventional metal-based microelectrodes. In this review, the multimodal sensing and stimulation functionalities of recent research are addressed. Next, issues that arise when combining functionalities of conventional metal-based, opaque electrode arrays together with optical modalities—(1) photoelectric artifacts, (2) optical image blocking, and (3) light transmission efficiency—are introduced. Then, an introduction of advancing material candidates for transparent neural interfaces follows with the latest research.

Original language	English
Article number	53
Journal	npj Flexible Electronics
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s41528-022-00178-4
Publication status	Published - 2022 Dec

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

All Science Journal Classification (ASJC) codes

General Materials Science
Electrical and Electronic Engineering

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10.1038/s41528-022-00178-4

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abstract = "The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods in a single tool. In conjunction with the integration of electrophysiology and optical modalities, a transparent neural interface alleviates challenges of conventional metal-based microelectrodes. In this review, the multimodal sensing and stimulation functionalities of recent research are addressed. Next, issues that arise when combining functionalities of conventional metal-based, opaque electrode arrays together with optical modalities—(1) photoelectric artifacts, (2) optical image blocking, and (3) light transmission efficiency—are introduced. Then, an introduction of advancing material candidates for transparent neural interfaces follows with the latest research.",

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AB - The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods in a single tool. In conjunction with the integration of electrophysiology and optical modalities, a transparent neural interface alleviates challenges of conventional metal-based microelectrodes. In this review, the multimodal sensing and stimulation functionalities of recent research are addressed. Next, issues that arise when combining functionalities of conventional metal-based, opaque electrode arrays together with optical modalities—(1) photoelectric artifacts, (2) optical image blocking, and (3) light transmission efficiency—are introduced. Then, an introduction of advancing material candidates for transparent neural interfaces follows with the latest research.

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Transparent neural implantable devices: a comprehensive review of challenges and progress

Abstract

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