Transition metal induced switch of fluorescence and absorption response of a Zn(ii)porphyrin-DNA conjugate to cysteine derivatives

Jung Kyu Choi, Gevorg Sargsyan, Breiana D. Johnson, Milan Balaz

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We report a supramolecular zinc(ii)tetraarylporphyrin-oligothymidine/metal ion system (ZnPorT8/M2+) for dual optical sensing of cysteine (Cys) and glutathione (GSH) with a tunable spectroscopic outcome. Transition metal ions (M2+ = Hg2+ or Cu2+) allow the switching of the emission and absorption response of the ZnPorT8/M2+ complex. The ZnPorT8/Hg2+ complex exhibits turn-on fluorescence sensing (fluorescence enhancement), whilst the ZnPorT8/Cu2+ system exhibits turn-off sensing (emission quenching) of Cys and GSH. The ZnPorT8/Hg2+ and ZnPorT8/Cu2+ complexes have an excellent limit of detection (LOD(em)) for Cys (5.95 nM and 11.99 nM, respectively) and GSH (3.34 nM and 13.50 nM, respectively).

Original languageEnglish
Pages (from-to)15916-15922
Number of pages7
JournalRSC Advances
Volume5
Issue number21
DOIs
Publication statusPublished - 2015

Bibliographical note

Publisher Copyright:
© 2015 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering

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