Transient expression of phospholipase D1 in developing rat hippocampus

Do Sik Min, Jeong Sun Choi, Myung Hoon Chun, Jin Woong Chung, Mun Yong Lee

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9 Citations (Scopus)


We investigated the distribution of phospholipase D1 (PLD1) protein in the developing rat hippocampus using an affinity-purified peptide antibody against PLD1. Immunoreactivity for PLD1 was first seen in some scattered cells in the hippocampus at embryonic day 18. At postnatal day 1 (P1), many PLD1 immunoreactive cells were observed in the CA1 and CA3 sectors, subiculum and the hilus of the dentate gyrus. During the first postnatal week, there was an abrupt increase of immunoreactive neurons in the hippocampus, and their number and intensity peaked at P7. During the second postnatal week, there was an abrupt decrease in the number of immunoreactive hippocampal neurons. By P14, no significant labeling was found in the hippocampus. These results corresponded well with those from Western blot analysis, suggesting that PLD1 may regulate the developmental processes of hippocampal neurons.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalNeuroscience Letters
Issue number2-3
Publication statusPublished - 2001 Sept 14

Bibliographical note

Funding Information:
The authors thank Mrs Hee-Duck Rho and Byoung-Ouk Hong for their excellent technical assistance. This work was supported by The Basic Research Program of the Korea Science & Engineering Foundation (Grant number: 2000-0-213-001-2).

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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