Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study

Hyeon Park; Donghee Park; Jongho Won; Jiyoung Jang; Bomi Hong; Yujin Park; Chulwoo Kim; Jongbum Seo

doi:10.1109/ULTSYM.2017.8091882

Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study

Hyeon Park, Donghee Park, Jongho Won, Jiyoung Jang, Bomi Hong, Yujin Park, Chulwoo Kim, Jongbum Seo

Division of Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In previous studies, we have found that addition of cavitation seed such as ultrasound contrast agents (UCA) in sonophoresis accelerate and increase efficiency of transdermal drug delivery (TDD). Actively-induced cavitation with low intensity ultrasound (less than 1 MPa) on the skin causes disordering of the lipid bilayers and the formation of aqueous channels. However, commercial UCAs also have limit, because mixed UCA is uniformly positioned in the water based solution, not on the skin surface. In order to enhance the TDD, the cavitation effect of cavitation seed should be generated near skin surface. For that reason, we manufactured specialized cavitation seed for TDD, which can be sank near skin surface by gravity. In order to make sure possibility of macromolecules delivery using cavitation seed, we performed in vivo experiment using sonophoresis with specialized cavitation seed.

Original language	English
Title of host publication	2017 IEEE International Ultrasonics Symposium, IUS 2017
Publisher	IEEE Computer Society
ISBN (Electronic)	9781538633830
DOIs	https://doi.org/10.1109/ULTSYM.2017.8091882
Publication status	Published - 2017 Oct 31
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: 2017 Sept 6 → 2017 Sept 9

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Other

Other	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	17/9/6 → 17/9/9

Bibliographical note

Publisher Copyright:
© 2017 IEEE.

All Science Journal Classification (ASJC) codes

Acoustics and Ultrasonics

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10.1109/ULTSYM.2017.8091882

Cite this

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title = "Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study",

abstract = "In previous studies, we have found that addition of cavitation seed such as ultrasound contrast agents (UCA) in sonophoresis accelerate and increase efficiency of transdermal drug delivery (TDD). Actively-induced cavitation with low intensity ultrasound (less than 1 MPa) on the skin causes disordering of the lipid bilayers and the formation of aqueous channels. However, commercial UCAs also have limit, because mixed UCA is uniformly positioned in the water based solution, not on the skin surface. In order to enhance the TDD, the cavitation effect of cavitation seed should be generated near skin surface. For that reason, we manufactured specialized cavitation seed for TDD, which can be sank near skin surface by gravity. In order to make sure possibility of macromolecules delivery using cavitation seed, we performed in vivo experiment using sonophoresis with specialized cavitation seed.",

author = "Hyeon Park and Donghee Park and Jongho Won and Jiyoung Jang and Bomi Hong and Yujin Park and Chulwoo Kim and Jongbum Seo",

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day = "31",

doi = "10.1109/ULTSYM.2017.8091882",

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Park, H, Park, D, Won, J, Jang, J, Hong, B, Park, Y, Kim, C & Seo, J 2017, Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8091882, IEEE International Ultrasonics Symposium, IUS, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 17/9/6. https://doi.org/10.1109/ULTSYM.2017.8091882

Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study. / Park, Hyeon; Park, Donghee; Won, Jongho et al.
2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8091882 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017

AU - Park, Hyeon

AU - Park, Donghee

AU - Won, Jongho

AU - Jang, Jiyoung

AU - Hong, Bomi

AU - Park, Yujin

AU - Kim, Chulwoo

AU - Seo, Jongbum

PY - 2017/10/31

Y1 - 2017/10/31

N2 - In previous studies, we have found that addition of cavitation seed such as ultrasound contrast agents (UCA) in sonophoresis accelerate and increase efficiency of transdermal drug delivery (TDD). Actively-induced cavitation with low intensity ultrasound (less than 1 MPa) on the skin causes disordering of the lipid bilayers and the formation of aqueous channels. However, commercial UCAs also have limit, because mixed UCA is uniformly positioned in the water based solution, not on the skin surface. In order to enhance the TDD, the cavitation effect of cavitation seed should be generated near skin surface. For that reason, we manufactured specialized cavitation seed for TDD, which can be sank near skin surface by gravity. In order to make sure possibility of macromolecules delivery using cavitation seed, we performed in vivo experiment using sonophoresis with specialized cavitation seed.

AB - In previous studies, we have found that addition of cavitation seed such as ultrasound contrast agents (UCA) in sonophoresis accelerate and increase efficiency of transdermal drug delivery (TDD). Actively-induced cavitation with low intensity ultrasound (less than 1 MPa) on the skin causes disordering of the lipid bilayers and the formation of aqueous channels. However, commercial UCAs also have limit, because mixed UCA is uniformly positioned in the water based solution, not on the skin surface. In order to enhance the TDD, the cavitation effect of cavitation seed should be generated near skin surface. For that reason, we manufactured specialized cavitation seed for TDD, which can be sank near skin surface by gravity. In order to make sure possibility of macromolecules delivery using cavitation seed, we performed in vivo experiment using sonophoresis with specialized cavitation seed.

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M3 - Conference contribution

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PB - IEEE Computer Society

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Transdermal delivery of macromolecule using sonophoresis with cavitation seed: In-vivo study

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