Transcriptomic Comparison Analysis between Ameloblastoma and AM-1 Cell Line

Shujin Li, Dong Joon Lee, Hyun Yi Kim, Hidemitsu Harada, Young Soo Jung, Han Sung Jung

Research output: Contribution to journalArticlepeer-review

Abstract

Cancer initiation and progression are profoundly along with the crosstalk between cancer cells and the surrounding stroma. Accumulating evidence has shown that the therapy targeting the extracellular matrix (ECM) would regress tumor growth and invasion in the most common carcinomas. However, it remains largely unexplored in several rare tumors like odontogenic tumors. Ameloblastoma (AM) is the representative odontogenic epithelial tumor in the jawbone, and it usually infiltrates into adjacent bone marrow and has unlimited growth capacity and a high potential for recurrence. This study aims to investigate the role of collagen-rich ECM during the invasion of AM. Transcriptomic analysis revealed that ECM and epithelial-to-mesenchymal transition (EMT)-related genes were up-regulated in AM compared to ameloblastoma cell line, AM-1. Tumoroid forming analysis showed that Collagen-rich ECM is indispensable for AM progression, especially for aggressive growth patterns and collective invasion.

Original languageEnglish
Pages (from-to)415-421
Number of pages7
JournalInternational Journal of Stem Cells
Volume15
Issue number4
DOIs
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 by the Korean Society for Stem Cell Research

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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