Trabecular bone response to mechanical loading in ovariectomized Sprague-Dawley rats depends on baseline bone quantity

Chang Yong Ko, Young Jin Jung, Ji Hyung Park, Donghyun Seo, Paul Han, Kiho Bae, Jürgen Schreiber, Han Sung Kim

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6 Citations (Scopus)


Mechanical loading is one of the determining factors for bone modulation, and is therefore frequently used to treat or prevent bone loss; however, there appears to be no data on the effects of baseline bone quantity on this response. This study aimed to verify whether baseline bone quantity affects osteoporotic trabecular bone adaptive response to mechanical stimulation. Twenty-four female Sprague-Dawley (SD) rats were ovariectomized (OVX). After 3 weeks of OVX, rats were divided into a high bone quantity and a low bone quantity group, and rats in each group were then subdivided into 4 groups that were exposed to different loading strategies. In the loading groups, tibiae were stimulated through axial loading at 2000 με of strain, for 1500 cycles each of 75. s, 150. s, or 250. s. The sham treatment groups received no loading. Changes in BV/TV for trabecular bone in the tibia were measured at the baseline (before loading), and at 3 weeks and 6 weeks after loading. BV/TVs in loading groups of the low baseline bone quantity group were significantly increased at 6 weeks, compared with those in the no-loading groups (p<0.05), while those in the high quantity groups were not increased (p>0.05). A significant negative correlation was observed between baseline BV/TV and its relative variations at 3 weeks or 6 weeks (p<0.05).These results indicate that adaptive responses of osteoporotic trabecular bone to mechanical loading depend on baseline bone quantity.

Original languageEnglish
Pages (from-to)2046-2049
Number of pages4
JournalJournal of Biomechanics
Issue number11
Publication statusPublished - 2012 Jul 26

Bibliographical note

Funding Information:
This research was supported by Leading Space Core Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) (2011-0030888) .

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation


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