Topographical pattern for neuronal tissue engineering

Madhumita Patel, Sujeong Ahn, Won Gun Koh

Research output: Contribution to journalReview articlepeer-review


Tissue engineering is an alternative medical approach to reconstructing neuronal injuries. Topographical features direct neuronal responses, such as cell adhesion, proliferation, morphological changes, alignment, and gene expression, which are controlled by the size, shape, and pattern of the adherent surface. Several studies have reported different aspects of neuronal behavior on aligned micro/nanopatterns and pillars. In this review, we focus on the recent progress in the development of topographical patterns for neuronal outgrowth, guidance, and differentiation. We discuss the neuronal responses to various patterns, such as grooves, fibers, and pillar patterns. These topographical features induce neuronal alignment and enhance their differentiation. Furthermore, we review the underlying mechanisms linked to the effects of micro- and nanopatterns.

Original languageEnglish
Pages (from-to)19-32
Number of pages14
JournalJournal of Industrial and Engineering Chemistry
Publication statusPublished - 2022 Oct 25

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT of the Korea government ( MSIT ) ( 2017M3D1A1039289 and 2020M3A914039045 ).

Publisher Copyright:
© 2022 The Korean Society of Industrial and Engineering Chemistry

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)


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