Topiramate on the quality of life in childhood epilepsy

Da Eun Jung; Heung Dong Kim; Yun Jung Hur; So Yong Eom

doi:10.1016/j.braindev.2010.11.011

Topiramate on the quality of life in childhood epilepsy

Da Eun Jung, Heung Dong Kim, Yun Jung Hur, So Yong Eom

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6. months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6. months after starting TPM treatment from the baseline-scores (P< 0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.

Original language	English
Pages (from-to)	707-712
Number of pages	6
Journal	Brain and Development
Volume	33
Issue number	9
DOIs	https://doi.org/10.1016/j.braindev.2010.11.011
Publication status	Published - 2011 Oct

Bibliographical note

Funding Information:
Study (ID.TOPATEPY4054) was funded by Janssen, Korea Ltd., a Johnson and Johnson company. The remaining authors have no conflicts of interest.

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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10.1016/j.braindev.2010.11.011

Cite this

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title = "Topiramate on the quality of life in childhood epilepsy",

abstract = "This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6. months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6. months after starting TPM treatment from the baseline-scores (P< 0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.",

author = "Jung, {Da Eun} and Kim, {Heung Dong} and Hur, {Yun Jung} and Eom, {So Yong}",

note = "Funding Information: Study (ID.TOPATEPY4054) was funded by Janssen, Korea Ltd., a Johnson and Johnson company. The remaining authors have no conflicts of interest. ",

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AU - Jung, Da Eun

AU - Kim, Heung Dong

AU - Hur, Yun Jung

AU - Eom, So Yong

N1 - Funding Information: Study (ID.TOPATEPY4054) was funded by Janssen, Korea Ltd., a Johnson and Johnson company. The remaining authors have no conflicts of interest.

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Topiramate on the quality of life in childhood epilepsy

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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