Topiramate on the quality of life in childhood epilepsy

Da Eun Jung, Heung Dong Kim, Yun Jung Hur, So Yong Eom

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6. months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6. months after starting TPM treatment from the baseline-scores (P< 0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalBrain and Development
Issue number9
Publication statusPublished - 2011 Oct

Bibliographical note

Funding Information:
Study (ID.TOPATEPY4054) was funded by Janssen, Korea Ltd., a Johnson and Johnson company. The remaining authors have no conflicts of interest.

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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