Top-down fabrication-based nano/microparticles for molecular imaging and drug delivery

Susmita Aryal, Hyungkyu Park, James F. Leary, Jaehong Key

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Recent breakthroughs in nanoparticle research have led to improved drug delivery and have overcome problems associated with normal drug delivery methods. Optimizing the design of nanoparticles in terms of controlled size, shape, and surface chemistry of nanoparticles can maximize the therapeutic efficacy. To maximize therapeutic effects, advanced formulation and fabrication methods have been developed. Biomedical applications of nanoparticles produced using the new fabrication techniques, including drug delivery and molecular imaging, have been widely explored. This review highlights the simple and versatile manufacturing techniques that can be used in the development of new types of nanoparticles that have strictly controlled physiochemical properties and their multifaceted advantages in drug delivery and molecular imaging.

Original languageEnglish
Pages (from-to)6631-6644
Number of pages14
JournalInternational journal of nanomedicine
Publication statusPublished - 2019

Bibliographical note

Publisher Copyright:
© 2019 Aryal et al.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


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