Tissue engineering of heart valves in vivo using bone marrow-derived cells

Sang Soo Kim, Sang Hyun Lim, Yoo Sun Hong, Seung Woo Cho, Ju Hee Ryu, Byung Chul Chang, Cha Yong Choi, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


In this study, we tissue-engineered heart valves in vivo using autologous bone marrow-derived cells (BMCs). Canine BMCs were differentiated into endothelial cell (EC)-like cells and myofibroblast (MF)-like cells. Decellularized porcine pulmonary valves were seeded with BMCs and implanted to abdominal aorta and pulmonary valve of bone marrow donor dogs. Histological examination of the explants identified the regeneration of valvular structures expressing CD31 and smooth muscle α-actin, indicating the presence of EC-like and MF-like cells in the grafts at 3 and 1 week, respectively, after implantation. Fluorescent microscopic examinations identified the presence of fluorescently labeled cells in the explants, indicating that the implanted BMCs survived and participated in the heart valve reconstitution. This study reports, for the first time, on tissue engineering of heart valve in vivo using BMCs.

Original languageEnglish
Pages (from-to)554-557
Number of pages4
JournalArtificial Organs
Issue number7
Publication statusPublished - 2006 Jul

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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