Thermosensitive chitosans as novel injectable biomaterials

Ho Jin Chung, Jin Woo Bae, Hyung Dal Park, Jin Woo Lee, Ki Dong Park

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Two kinds of water soluble thermosensitive chitosan copolymers were prepared by graft polymerization of N-isopropylacrylamide (NIPAAm) onto chitosan using cerium ammonium nitrate (CAN) as an initiator (chitosan-g-NIPAAm) and by coupling monocarboxy Pluronic® with chitosan using 1-ethyl-3-(3- dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as coupling agents (chitosan-Pluronic®). The physicochemical properties of the resulting copolymers were characterized and they formed thermally reversible hydrogel, which exhibits a lower critical solution temperature (LCST) at 34°C in aqueous solutions. The human mesenchymal stem cells (hMSCs) were cultured in the chiotsan-g-NIPAAm in vitro. Chondrogenic differentiation was induced in the chitosan-g-NIPAAm gel. Therefore, chondrogenic differentiated cells from MSCs with a thermosensitive chitosan-g-NIPAAm could be used as an injectable cell-polymer complex. In summary, chitosan-g-NIPAAm and chitosan-Pluronic® attest to their usefulness as injectable materials because of their thermally reversible property and relatively good biocompatibility.

Original languageEnglish
Pages (from-to)275-286
Number of pages12
JournalMacromolecular Symposia
Publication statusPublished - 2005 Apr

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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