TY - JOUR
T1 - Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats
AU - Park, Joohyun
AU - Kim, Jong Youl
AU - Choi, Seong Kyoon
AU - Kim, Jae Young
AU - Kim, Jae Hwan
AU - Jeon, Won Bae
AU - Lee, Jong Eun
N1 - Publisher Copyright:
© 2017 The Author(s)
PY - 2017/8
Y1 - 2017/8
N2 - Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.
AB - Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.
KW - Elastin-like polypeptide
KW - Intracerebral hemorrhage
KW - Nanomaterial
KW - RGD-containing elastin-like polypeptide
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U2 - 10.1016/j.nano.2017.04.001
DO - 10.1016/j.nano.2017.04.001
M3 - Article
C2 - 28412143
AN - SCOPUS:85020776494
SN - 1549-9634
VL - 13
SP - 1853
EP - 1862
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 6
ER -