The value of brachial-ankle pulse wave velocity as a predictor of coronary artery disease in high-risk patients

Won Woo Seo, Hyuk Jae Chang, Ik Sung Cho, Yeon Yee Yoon, Jung Won Suh, Kwang Il Kim, Yong Seok Cho, Tae Jin Youn, In Ho Chae, Dong Ju Choi, Cheol Ho Kim, Eun Ju Chun, Sang Il Choi

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23 Citations (Scopus)


Background and Objectives: Arterial stiffness has been known as an independent contributory factor for coronary artery disease (CAD). Brachial-ankle puke wave velocity (baPWV) is widely used as a simple noninvasive measure of arterial stiffness. The aim of our study was to test whether baPWV had predictive value for CAD in the subset of patients with high pretest probability. Subjects and Methods: We enrolled 174 consecutive patients who were referred for evaluation of suspected CAD, and who underwent both baPWV measurement and computed tomography (CT) for coronary artery calcium scoring (CACS) as part of a diagnostic work-up. Subsequently, 160 of those patients underwent invasive coronary angiography. The CAD indices consisted of 1) CACS, 2) modified Gensini scoring system, and 3) presence of obstructive CAD and 4) multi-vessel obstructive CAD. Results: baPWV correlated with CACS (r=0.25, p=0.001), but not with modified Gensini scoring (r=0.10, p=0.19). However, after adjustment for factors influencing PWV, baPWV no longer correlated with CACS (r=0.14, p=0.14). By receiver operating characteristic (ROC) curve analysis, baPWV was neither a sensitive nor specific index for predicting the presence of obstructive CAD or multi-vessel obstructive CAD (sensitivity: 53% and 59%; specificity: 50% and 55%, respectively). Conclusion: Our findings demonstrated that baPWV is associated with CACS, however, this may be primarily attributed to common risk factors, such as age. Furthermore, baPWV may be of limited value in identifying patients at risk for CAD.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalKorean Circulation Journal
Issue number5
Publication statusPublished - 2010 May

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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