The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin

Yangsoo Jang; Jong Ho Lee; Oh Yoen Kim; Soo Jeong Koh; Jey Sook Chae; Jin Hee Woo; Hongkeun Cho; Jong Eun Lee; Jose M. Ordovas

doi:10.1016/j.metabol.2005.07.007

The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin

Yangsoo Jang, Jong Ho Lee, Oh Yoen Kim, Soo Jeong Koh, Jey Sook Chae, Jin Hee Woo, Hongkeun Cho, Jong Eun Lee, Jose M. Ordovas

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Abstract

This study aimed to determine whether polymorphisms of the adiponectin (ACDC) gene independently contribute to insulin resistance (IR) and other cardiovascular disease (CVD) risk factors in nonobese, nondiabetic Korean men after adjusting for major environmental factors that influence IR. Among the 7 ACDC single-nucleotide polymorphisms (SNPs;C-11377G, T45G, G276T, H241P, Y111H, G90S, and R221S) prescreened in 48 subjects, we genotyped 333 subjects for SNP45 and SNP276, both of which showed an allele frequency of more than 2%. In Pearson correlation and multiple stepwise regression analyses, we found that waist circumference was the most important influencing factor (β = .369, P < .001) in homeostasis model assessment (HOMA)-IR, whereas plasma adiponectin was the second most important (β = -.217, P = .023). At position 276, T/T subjects showed significantly lower glucose concentrations (P = .043) and higher low-density lipoprotein particle sizes (P = .033) than the G/G and G/T subjects. The subjects also had lower serum triglycerides and HOMA-IR; however, these results were not statistically significant. After adjusting for waist circumference and plasma adiponectin, T/T subjects showed a significantly lower HOMA-IR than G/G or G/T subjects (P = .048). On the other hand, at position 45, only glucose concentrations were significantly lower in G carriers (P = .005). In the SNP45-SNP276 haplotype test, TT/TT subjects (having T/T at both SNP45 and SNP276) showed significantly lower IR before and after adjusting for waist circumference and adiponectin levels than did other carriers. In conclusion, we suggest that SNP276G>T, rather than SNP45T>G, is more strongly associated (both directly and indirectly) than with several components of metabolic syndrome and CVD risk, including IR, triglyceride concentration, and low-density lipoprotein particle size, in nonobese, nondiabetic men.

Original language	English
Pages (from-to)	59-66
Number of pages	8
Journal	Metabolism: Clinical and Experimental
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/j.metabol.2005.07.007
Publication status	Published - 2006 Jan

Bibliographical note

Funding Information:
This study was supported in part by the Korea Science and Engineering Foundation (R01-2003-0000-11709-0); Korea Health 21 R&D Projects, Ministry of Health, and Welfare (00-PJ3-PG6-GN-01-0001); National Research Laboratory project no. 2005-01572, Ministry of Science and Technology, Korea; National Institutes of Health/National Heart, Lung, and Blood Institute grant HL54776 and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service.

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Endocrinology, Diabetes and Metabolism
Endocrinology

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Jang, Y., Lee, J. H., Kim, O. Y., Koh, S. J., Chae, J. S., Woo, J. H., Cho, H., Lee, J. E., & Ordovas, J. M. (2006). The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism: Clinical and Experimental, 55(1), 59-66. https://doi.org/10.1016/j.metabol.2005.07.007

Jang, Yangsoo ; Lee, Jong Ho ; Kim, Oh Yoen et al. / The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. In: Metabolism: Clinical and Experimental. 2006 ; Vol. 55, No. 1. pp. 59-66.

@article{dc357931a24044dda446998124dc4a76,

title = "The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin",

abstract = "This study aimed to determine whether polymorphisms of the adiponectin (ACDC) gene independently contribute to insulin resistance (IR) and other cardiovascular disease (CVD) risk factors in nonobese, nondiabetic Korean men after adjusting for major environmental factors that influence IR. Among the 7 ACDC single-nucleotide polymorphisms (SNPs;C-11377G, T45G, G276T, H241P, Y111H, G90S, and R221S) prescreened in 48 subjects, we genotyped 333 subjects for SNP45 and SNP276, both of which showed an allele frequency of more than 2%. In Pearson correlation and multiple stepwise regression analyses, we found that waist circumference was the most important influencing factor (β = .369, P < .001) in homeostasis model assessment (HOMA)-IR, whereas plasma adiponectin was the second most important (β = -.217, P = .023). At position 276, T/T subjects showed significantly lower glucose concentrations (P = .043) and higher low-density lipoprotein particle sizes (P = .033) than the G/G and G/T subjects. The subjects also had lower serum triglycerides and HOMA-IR; however, these results were not statistically significant. After adjusting for waist circumference and plasma adiponectin, T/T subjects showed a significantly lower HOMA-IR than G/G or G/T subjects (P = .048). On the other hand, at position 45, only glucose concentrations were significantly lower in G carriers (P = .005). In the SNP45-SNP276 haplotype test, TT/TT subjects (having T/T at both SNP45 and SNP276) showed significantly lower IR before and after adjusting for waist circumference and adiponectin levels than did other carriers. In conclusion, we suggest that SNP276G>T, rather than SNP45T>G, is more strongly associated (both directly and indirectly) than with several components of metabolic syndrome and CVD risk, including IR, triglyceride concentration, and low-density lipoprotein particle size, in nonobese, nondiabetic men.",

author = "Yangsoo Jang and Lee, {Jong Ho} and Kim, {Oh Yoen} and Koh, {Soo Jeong} and Chae, {Jey Sook} and Woo, {Jin Hee} and Hongkeun Cho and Lee, {Jong Eun} and Ordovas, {Jose M.}",

note = "Funding Information: This study was supported in part by the Korea Science and Engineering Foundation (R01-2003-0000-11709-0); Korea Health 21 R&D Projects, Ministry of Health, and Welfare (00-PJ3-PG6-GN-01-0001); National Research Laboratory project no. 2005-01572, Ministry of Science and Technology, Korea; National Institutes of Health/National Heart, Lung, and Blood Institute grant HL54776 and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service. ",

year = "2006",

month = jan,

doi = "10.1016/j.metabol.2005.07.007",

language = "English",

volume = "55",

pages = "59--66",

journal = "Metabolism: Clinical and Experimental",

issn = "0026-0495",

publisher = "W.B. Saunders Ltd",

number = "1",

}

Jang, Y , Lee, JH, Kim, OY, Koh, SJ, Chae, JS, Woo, JH, Cho, H, Lee, JE & Ordovas, JM 2006, 'The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin', Metabolism: Clinical and Experimental, vol. 55, no. 1, pp. 59-66. https://doi.org/10.1016/j.metabol.2005.07.007

The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. / Jang, Yangsoo ; Lee, Jong Ho; Kim, Oh Yoen et al.
In: Metabolism: Clinical and Experimental, Vol. 55, No. 1, 01.2006, p. 59-66.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin

AU - Jang, Yangsoo

AU - Lee, Jong Ho

AU - Kim, Oh Yoen

AU - Koh, Soo Jeong

AU - Chae, Jey Sook

AU - Woo, Jin Hee

AU - Cho, Hongkeun

AU - Lee, Jong Eun

AU - Ordovas, Jose M.

N1 - Funding Information: This study was supported in part by the Korea Science and Engineering Foundation (R01-2003-0000-11709-0); Korea Health 21 R&D Projects, Ministry of Health, and Welfare (00-PJ3-PG6-GN-01-0001); National Research Laboratory project no. 2005-01572, Ministry of Science and Technology, Korea; National Institutes of Health/National Heart, Lung, and Blood Institute grant HL54776 and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service.

PY - 2006/1

Y1 - 2006/1

N2 - This study aimed to determine whether polymorphisms of the adiponectin (ACDC) gene independently contribute to insulin resistance (IR) and other cardiovascular disease (CVD) risk factors in nonobese, nondiabetic Korean men after adjusting for major environmental factors that influence IR. Among the 7 ACDC single-nucleotide polymorphisms (SNPs;C-11377G, T45G, G276T, H241P, Y111H, G90S, and R221S) prescreened in 48 subjects, we genotyped 333 subjects for SNP45 and SNP276, both of which showed an allele frequency of more than 2%. In Pearson correlation and multiple stepwise regression analyses, we found that waist circumference was the most important influencing factor (β = .369, P < .001) in homeostasis model assessment (HOMA)-IR, whereas plasma adiponectin was the second most important (β = -.217, P = .023). At position 276, T/T subjects showed significantly lower glucose concentrations (P = .043) and higher low-density lipoprotein particle sizes (P = .033) than the G/G and G/T subjects. The subjects also had lower serum triglycerides and HOMA-IR; however, these results were not statistically significant. After adjusting for waist circumference and plasma adiponectin, T/T subjects showed a significantly lower HOMA-IR than G/G or G/T subjects (P = .048). On the other hand, at position 45, only glucose concentrations were significantly lower in G carriers (P = .005). In the SNP45-SNP276 haplotype test, TT/TT subjects (having T/T at both SNP45 and SNP276) showed significantly lower IR before and after adjusting for waist circumference and adiponectin levels than did other carriers. In conclusion, we suggest that SNP276G>T, rather than SNP45T>G, is more strongly associated (both directly and indirectly) than with several components of metabolic syndrome and CVD risk, including IR, triglyceride concentration, and low-density lipoprotein particle size, in nonobese, nondiabetic men.

AB - This study aimed to determine whether polymorphisms of the adiponectin (ACDC) gene independently contribute to insulin resistance (IR) and other cardiovascular disease (CVD) risk factors in nonobese, nondiabetic Korean men after adjusting for major environmental factors that influence IR. Among the 7 ACDC single-nucleotide polymorphisms (SNPs;C-11377G, T45G, G276T, H241P, Y111H, G90S, and R221S) prescreened in 48 subjects, we genotyped 333 subjects for SNP45 and SNP276, both of which showed an allele frequency of more than 2%. In Pearson correlation and multiple stepwise regression analyses, we found that waist circumference was the most important influencing factor (β = .369, P < .001) in homeostasis model assessment (HOMA)-IR, whereas plasma adiponectin was the second most important (β = -.217, P = .023). At position 276, T/T subjects showed significantly lower glucose concentrations (P = .043) and higher low-density lipoprotein particle sizes (P = .033) than the G/G and G/T subjects. The subjects also had lower serum triglycerides and HOMA-IR; however, these results were not statistically significant. After adjusting for waist circumference and plasma adiponectin, T/T subjects showed a significantly lower HOMA-IR than G/G or G/T subjects (P = .048). On the other hand, at position 45, only glucose concentrations were significantly lower in G carriers (P = .005). In the SNP45-SNP276 haplotype test, TT/TT subjects (having T/T at both SNP45 and SNP276) showed significantly lower IR before and after adjusting for waist circumference and adiponectin levels than did other carriers. In conclusion, we suggest that SNP276G>T, rather than SNP45T>G, is more strongly associated (both directly and indirectly) than with several components of metabolic syndrome and CVD risk, including IR, triglyceride concentration, and low-density lipoprotein particle size, in nonobese, nondiabetic men.

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Jang Y , Lee JH, Kim OY, Koh SJ, Chae JS, Woo JH et al. The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism: Clinical and Experimental. 2006 Jan;55(1):59-66. doi: 10.1016/j.metabol.2005.07.007

The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin

Abstract

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