Excessive bone resorption by osteoclasts relative to bone formation by osteoblasts results in the development of osteoporosis. Anti-osteoporotic agents that are able both to inhibit bone resorption and to stimulate bone formation are not available. We now show that water-soluble nacreous factors prepared from the pearl oyster Pteria martensii prevent osteoporotic bone loss associated with estrogen deficiency in mice mainly through osteoclast inactivation. Nacreous factors stimulated osteoblast biomineralization in vitro in association with activation of signaling by c-Jun NH2-terminal kinase (JNK) and Fos-related antigen-1 (Fra-1). They also suppressed both osteoclast formation by blocking up-regulation of nuclear factor of activated T cells cytoplasmic 1 (NFATc1) as well as bone pit formation mediated by mature osteoclasts, likely by disrupting the actin ring of these cells. Our findings thus show that the components of a natural material have beneficial effects on bone remodeling that are mediated through regulation of both osteoblast and osteoclast function. They may thus provide a basis for the development of biomimetic bone material as well as anti-osteoporotic agents.
|Number of pages||8|
|Publication status||Published - 2012 Oct|
Bibliographical noteFunding Information:
We thank J. S. Bae (Uiseong Oriental Medicine Hospital, Korea) for helpful discussion on the clinical efficacy of nacre. This work was supported, in part, by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (no. A084221 to DJ) and from the National Research Foundation of Korea (nos. 2011-0006178 to DJ and 2011-0002984 to SHL).
All Science Journal Classification (ASJC) codes
- Mechanics of Materials
- Ceramics and Composites