The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells

Tae Il Kim; Soo Hyun Jin; Eun Hye Kang; Sung Kwan Shin; Kang Yell Choi; Won Ho Kim

doi:10.1111/j.1749-6632.2002.tb04641.x

The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells

Tae Il Kim, Soo Hyun Jin, Eun Hye Kang, Sung Kwan Shin, Kang Yell Choi, Won Ho Kim

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.

Original language	English
Pages (from-to)	241-245
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	973
DOIs	https://doi.org/10.1111/j.1749-6632.2002.tb04641.x
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1749-6632.2002.tb04641.x

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title = "The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells",

abstract = "We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.",

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T1 - The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells

AU - Kim, Tae Il

AU - Jin, Soo Hyun

AU - Kang, Eun Hye

AU - Shin, Sung Kwan

AU - Choi, Kang Yell

AU - Kim, Won Ho

PY - 2002

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N2 - We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.

AB - We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.

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JO - Annals of the New York Academy of Sciences

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The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells

Abstract

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