The role of IL-13 in established allergic airway disease

Christian Taube, Catherine Duez, Zhi Hua Cui, Katsuyuki Takeda, Yeong Ho Rha, Jung Won Park, Annette Balhorn, Debra D. Donaldson, Azzeddine Dakhama, Erwin W. Gelfand

Research output: Contribution to journalArticlepeer-review

162 Citations (Scopus)


The effectiveness of targeting IL-13 in models where airway hyperresponsiveness (AHR) and airway inflammation have already been established is not well-described. We investigated the effects of blocking IL-13 on the early and late phase airway responses and the development of AHR in previously sensitized and challenged mice. BALB/cByJ mice were sensitized (days 1 and 14) and challenged (days 28-30) with OVA. Six weeks later (day 72), previously sensitized/challenged mice were challenged with a single OVA aerosol and the early and late phase response and development of AHR were determined. Specific in vivo blockade of IL-13 was attained after i.p. injection of a soluble IL-13Rα2-IgG fusion protein (sIL-13Rα2Fc) on days 71-72 for the early and late responses and on days 71-73 for the development of AHR. sIL-13Rα2Fc administration inhibited the late, but not early, phase response and the OVA challenge-induced changes in lung resistance and dynamic compliance; as well, sIL-13Rα2Fc administration decreased bronchoalveolar lavage eosinophilia and mucus hypersecretion following the secondary challenge protocols. These results demonstrate that targeting IL-13 alone regulates airway responses when administrated to mice with established allergic airway disease. These data identify the importance of IL-13 in the development of allergen-induced altered airway responsiveness following airway challenge, even when administered before rechallenge of mice in which allergic disease had been previously established.

Original languageEnglish
Pages (from-to)6482-6489
Number of pages8
JournalJournal of Immunology
Issue number11
Publication statusPublished - 2002 Dec 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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