The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients

P. W. Roche; W. J. Britton; K. Dev Neupane; S. S. Failbus; S. N. Cho; W. J. Theuvenet

doi:10.4269/ajtmh.1991.44.702

The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients

P. W. Roche, W. J. Britton, K. Dev Neupane, S. S. Failbus, S. N. Cho, W. J. Theuvenet

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.

Original language	English
Pages (from-to)	702-708
Number of pages	7
Journal	American Journal of Tropical Medicine and Hygiene
Volume	44
Issue number	6
DOIs	https://doi.org/10.4269/ajtmh.1991.44.702
Publication status	Published - 1991

All Science Journal Classification (ASJC) codes

Parasitology
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4269/ajtmh.1991.44.702

Cite this

@article{4898bf9bf0094b0d8f4c593c3bddaafd,

title = "The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients",

abstract = "We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.",

author = "Roche, {P. W.} and Britton, {W. J.} and {Dev Neupane}, K. and Failbus, {S. S.} and Cho, {S. N.} and Theuvenet, {W. J.}",

year = "1991",

doi = "10.4269/ajtmh.1991.44.702",

language = "English",

volume = "44",

pages = "702--708",

journal = "American Journal of Tropical Medicine and Hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "6",

}

TY - JOUR

T1 - The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients

AU - Roche, P. W.

AU - Britton, W. J.

AU - Dev Neupane, K.

AU - Failbus, S. S.

AU - Cho, S. N.

AU - Theuvenet, W. J.

PY - 1991

Y1 - 1991

N2 - We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.

AB - We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.

UR - http://www.scopus.com/inward/record.url?scp=0026349745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026349745&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.1991.44.702

DO - 10.4269/ajtmh.1991.44.702

M3 - Article

C2 - 1858971

AN - SCOPUS:0026349745

SN - 0002-9637

VL - 44

SP - 702

EP - 708

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 6

ER -

The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this