The relationship between insulin-like growth factor-1 and metabolic syndrome, independent of adiponectin

Jaewon Oh, Jong Youn Kim, Sungha Park, Jong Chan Youn, Nak Hoon Son, Dong Jik Shin, Sang Hak Lee, Seok Min Kang, Sun Ha Jee, Yangsoo Jang

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20 Citations (Scopus)


Background: Insulin-like growth factor-1 (IGF-1) is associated with obesity and aging, and was recently linked to metabolic syndrome (MetS) and insulin resistance. However, little is known about the relationship between IGF-1 and adiponectin (adiponectin), another marker of MetS. Methods: We measured the plasma IGF-1 and adiponectin levels of 3099 subjects (1869 males, 55.9. ± 10.8. y). We applied the Korean-modified International Diabetes Foundation (k-IDF) criteria for determination of, and risk assessment for, MetS. Results: K-IDF criteria-based MetS occurred in 37.0% (n = 1146) of patients. IGF-1 (91.5 vs. 97.3. ng/ml, p. < 0.001) and adiponectin (3.95 vs. 4.23. μg/ml, p. < 0.001) were significantly lower in MetS patients than without MetS. Lower IGF-1 was associated with increasing numbers of MetS abnormalities, independent of adiponectin (p for trend. < 0.001, F = 12.615, p. < 0.001 in ANCOVA). MetS prevalence in individuals with both high IGF-1 and adiponectin levels (6.7%, n = 206) was significantly lower than in other groups. Both high IGF-1 and adiponectin group was associated with reduced MetS risk after adjusting for other confounding factors (OR 0.694, 95% CI 0.493-0.977, p = 0.036). Conclusions: IGF-1 was associated with MetS independent of adiponectin in our study. The independent relationship between IGF-1 and MetS provides insight into the pathophysiologic mechanisms of MetS.

Original languageEnglish
Pages (from-to)506-510
Number of pages5
JournalClinica Chimica Acta
Issue number3-4
Publication statusPublished - 2012 Feb 18

Bibliographical note

Funding Information:
This study was supported by a grant A000385 from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea , and by a grant 2010-0020766 from the Public welfare & Safety research program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea .

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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