The paradoxical protective effect of liver steatosis on severity and functional outcome of ischemic stroke

Minyoul Baik, Seung Up Kim, Hyo Suk Nam, Ji Hoe Heo, Young Dae Kim

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8 Citations (Scopus)


Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patients with first-ever acute ischemic stroke or TIA, who underwent transient elastography from January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Stroke Scale (NIHSS), was investigated using robust regression analysis. We also compared the functional outcome at 90 days according to the presence or burden of liver steatosis. Results: NAFLD was observed in 206 (64.2%) patients. Patients with NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = 0.012) and more favorable functional outcome at 90 days (85.3 vs. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower [95% confidence interval (CI), −39.2 to −3.2%, P = 0.026] NIHSS score and a 2.5-fold higher (95% CI, 1.08–5.67, P = 0.033) possibility of favorable functional outcome in multivariate analysis. Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA.

Original languageEnglish
Article number375
JournalFrontiers in Neurology
Issue numberAPR
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by a grant of the Korea Heath Technology R&D Project through the Korea Health Industry Development, funded by the Ministry of Health & Welfare, Republic of Korea (HI08C2149).

Publisher Copyright:
© 2019 Baik, Kim, Nam, Heo and Kim.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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