The Obesity Paradox in Cancer: Epidemiologic Insights and Perspectives

Dong Hoon Lee, Edward L. Giovannucci

Research output: Contribution to journalReview articlepeer-review

79 Citations (Scopus)

Abstract

Purpose of Review: Controversy exists whether excess body fatness (measured by body mass index (BMI)) is associated with better cancer survival (“obesity paradox”). Here, we review the obesity paradox in cancer research and discuss potential explanations and future research directions. Recent Findings: Overweight and obese cancer patients have better survival for diverse cancers. This apparent obesity paradox may be largely explained by methodological limitations including reverse causation, selection bias, confounding, and reliance of BMI as a measure of adiposity in cancer patients. A growing number of studies show promising evidence that precisely quantified body composition can provide important prognostic information in cancer care, such that low muscle and high adiposity are associated with worse clinical outcomes in cancer patients. Summary: The term obesity paradox in cancer, implying a causally beneficial role of adiposity, is misleading. Understanding the role of muscle and adiposity may reduce the confusion and inform precision oncology care.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalCurrent Nutrition Reports
Volume8
Issue number3
DOIs
Publication statusPublished - 2019 Sept 15

Bibliographical note

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

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