The lysosome as a novel therapeutic target of EGFR-mediated tumor inflammation

Woo Jung Sung, Dohyang Kim, Anlin Zhu, Namki Cho, Hee Min Yoo, Ji Heon Noh, Kyoung Mi Kim, Hyun Su Lee, Jaewoo Hong

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)


EGFR-mediated tumors have been targeted to overcome several different malignant cancers. EGFR overexpression and mutations are directly related to the malignancy, which makes the therapy more complicated. One reason for the malignancy is the induction of AP1 followed by inflammation via IL-6 secretion. Current therapeutic strategies to overcome EGFR-mediated tumors are tyrosine kinase inhibitors (TKIs), anti-EGFR monoclonal antibodies, and the combination of these two agents with classic chemotherapy or immune checkpoint inhibitors (ICIs). Although the strategies are straightforward and have shown promising efficacy in several studies, there are still hurdles to overcoming the adverse effects and limited efficacy. This study reviews the current therapeutic strategies to target EGFR family members, how they work, and their effects and limitations. We also suggest developing novel strategies to target EGFR-mediated tumors in a novel approach. A lysosome is the main custodial staff to discard unwanted amounts of EGFR and other receptor tyrosine kinase molecules. Targeting this organelle may be a new approach to overcoming EGFR-mediated cancers.

Original languageEnglish
Article number1050758
JournalFrontiers in Pharmacology
Publication statusPublished - 2022 Nov 11

Bibliographical note

Publisher Copyright:
Copyright © 2022 Sung, Kim, Zhu, Cho, Yoo, Noh, Kim, Lee and Hong.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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