The impact of dialysis modality on arterial stiffness in patients with end-stage renal disease

Jae Hyun Chang, Se Jung Yoon, Seung Hyeok Han, Sug Kyun Shin, Dong Woon Jeon, Joo Young Yang, Ea Wha Kang

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Arterial stiffness determined by brachialankle pulse wave velocity (baPWV) has been established as a powerful predictor of cardiovascular mortality in hemodialysis (HD) patients. There are, however, few studies regarding the comparative impact of different renal replacement therapies (RRTs) on PWV. Therefore, we conducted a cross-sectional study to compare arterial wall properties and cardiac function between patients treated with continuous ambulatory peritoneal dialysis (CAPD) and those with HD who were matched for age, dialysis duration, and blood pressure. Methods: baPWV and transthoracic echocardiography (TTE) were performed in HD patients (n = 23) after 1 h of midweek dialysis session and CAPD patients (n = 26) with empty abdomen after drainage of dialysate. The baseline data were retrospectively reviewed. Results: baPWV was significantly higher in HD patients than in CAPD patients (18.1 ± 2.8 vs. 16.1 ± 2.7 ms, p = 0.015). TTE revealed significantly increased EE′, left atrial volume index (LAVI), and inferior vena cava (IVC) diameter index in HD patients compared with CAPD patients (p < 0.05). In a multivariate regression analysis adjusted for dialysis modality, age, systolic BP, residual glomerular filtration rate, diabetes, and echocardiographic parameters, HD was independently associated with increased baPWV. Conclusion: This study showed that HD patients had significantly increased arterial stiffness and severe diastolic dysfunction compared with CAPD patients.

Original languageEnglish
Pages (from-to)947-953
Number of pages7
JournalRenal Failure
Issue number8
Publication statusPublished - 2010 Sept

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine
  • Nephrology


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