TY - JOUR
T1 - The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer
AU - Koo, Ja Seung
AU - Park, Seho
AU - Kim, Seung Il
AU - Lee, Sarah
AU - Park, Byeong Woo
PY - 2011/8
Y1 - 2011/8
N2 - We aimed to investigate the expression of caveolin- 1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.
AB - We aimed to investigate the expression of caveolin- 1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.
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U2 - 10.1007/s13277-011-0181-6
DO - 10.1007/s13277-011-0181-6
M3 - Article
C2 - 21584795
AN - SCOPUS:80052313683
SN - 1010-4283
VL - 32
SP - 787
EP - 799
JO - Tumor Biology
JF - Tumor Biology
IS - 4
ER -
