The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group

Jae Hee Cho; Ja Sung Choi; Song Wook Chun; Sangheun Lee; Ki Jun Han; Hee Man Kim

doi:10.5009/gnl15129

The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group

Jae Hee Cho, Ja Sung Choi, Song Wook Chun, Sangheun Lee, Ki Jun Han, Hee Man Kim

Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.

Original language	English
Pages (from-to)	362-368
Number of pages	7
Journal	Gut and liver
Volume	10
Issue number	3
DOIs	https://doi.org/10.5009/gnl15129
Publication status	Published - 2016

Bibliographical note

Publisher Copyright:
© This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

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10.5009/gnl15129

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@article{5a148dbc4b7948ebadba2edfe5e04aaf,

title = "The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group",

abstract = "Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.",

author = "Cho, {Jae Hee} and Choi, {Ja Sung} and Chun, {Song Wook} and Sangheun Lee and Han, {Ki Jun} and Kim, {Hee Man}",

note = "Publisher Copyright: {\textcopyright} This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.",

year = "2016",

doi = "10.5009/gnl15129",

language = "English",

volume = "10",

pages = "362--368",

journal = "Gut and liver",

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TY - JOUR

T1 - The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group

AU - Cho, Jae Hee

AU - Choi, Ja Sung

AU - Chun, Song Wook

AU - Lee, Sangheun

AU - Han, Ki Jun

AU - Kim, Hee Man

N1 - Publisher Copyright: © This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.

PY - 2016

Y1 - 2016

N2 - Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.

AB - Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1β, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1β-581C/T [rs1143627], IL-1β-1061C/T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (IL-1β IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1β-581C/T, and the CT/TT genotypes of IL-1β-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1β-581C/T and IL-1β-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.

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U2 - 10.5009/gnl15129

DO - 10.5009/gnl15129

M3 - Article

C2 - 26601827

AN - SCOPUS:84969268062

SN - 1976-2283

VL - 10

SP - 362

EP - 368

JO - Gut and liver

JF - Gut and liver

IS - 3

ER -

The IL-1B genetic polymorphism is associated with aspirin-induced peptic ulcers in a Korean ethnic group

Abstract

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