The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer

Ji Soo Park; Jae Seok Lee; Eun Young Kim; Ji Ye Jung; Se Kyu Kim; Joon Chang; Dae Joon Kim; Chang Young Lee; Inkyung Jung; Joo Hang Kim; Hye Ryun Kim; Yong Wha Moon; Hyo Song Kim; Byoung Chul Cho; Hyo Sup Shim

doi:10.1016/j.lungcan.2015.03.002

The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer

Ji Soo Park, Jae Seok Lee, Eun Young Kim, Ji Ye Jung, Se Kyu Kim, Joon Chang, Dae Joon Kim, Chang Young Lee, Inkyung Jung, Joo Hang Kim, Hye Ryun Kim, Yong Wha Moon, Hyo Song Kim, Byoung Chul Cho, Hyo Sup Shim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objectives: Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in many human cancers. We tried to identify the frequency of FGFR1 amplifications among Korean patients with small cell lung cancer (SCLC). Additionally, we examined the clinical significance of FGFR1 amplifications for overall survival (OS) and progression-free survival (PFS) among SCLC patients who received standard chemotherapies. Materials and methods: Tumor tissues from 158 Korean patients diagnosed with SCLC from September 2009 to February 2013 were collected and analyzed using an FGFR1 FISH assay with a probe that hybridized to chromosome region 8p12-8p11.23 (Abbott Molecular, Abbott Park, IL). Results and conclusion: FGFR1 amplification was detected in three patients (1.9%) harboring extensive disease (ED). A multivariate analysis showed that among the patients with ED, FGFR1 amplification was associated with shorter disease-free survival to first-line chemotherapy with etoposide plus cisplatin or carboplatin (hazard ratio [HR] = 7.1; 95% confidence interval [CI] = 2.0-25.4; P = 0.003). The median overall survival time of the patients with ED was 8.2 and 10.2 months among patients with and without FGFR1 amplification, respectively (P = 0.37). Although FGFR1 amplification is rare in SCLC compared to non-small cell lung cancer or other malignancies with squamous histology, it is associated with poor survival following standard chemotherapy in SCLC. Further studies in large cohorts of patients with SCLC are needed to verify these results. Our results imply that FGFR1 may be a potential therapeutic target in SCLC and it could be confirmed in a clinical trial.

Original language	English
Pages (from-to)	325-331
Number of pages	7
Journal	Lung Cancer
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2015.03.002
Publication status	Published - 2015 Jun 1

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( HI12C1440 , B.C. Cho), and a faculty research grant of Yonsei University College of Medicine for 2012 and 2013 ( 6-2012-0043 ; 6-2013-0016 to H.S. Shim).

Publisher Copyright:
© 2015 Elsevier Ireland Ltd.

All Science Journal Classification (ASJC) codes

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2015.03.002

Cite this

Park, J. S., Lee, J. S., Kim, E. Y., Jung, J. Y., Kim, S. K., Chang, J., Kim, D. J., Lee, C. Y., Jung, I., Kim, J. H., Kim, H. R., Moon, Y. W., Kim, H. S., Cho, B. C., & Shim, H. S. (2015). The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer. Lung Cancer, 88(3), 325-331. https://doi.org/10.1016/j.lungcan.2015.03.002

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title = "The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer",

abstract = "Objectives: Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in many human cancers. We tried to identify the frequency of FGFR1 amplifications among Korean patients with small cell lung cancer (SCLC). Additionally, we examined the clinical significance of FGFR1 amplifications for overall survival (OS) and progression-free survival (PFS) among SCLC patients who received standard chemotherapies. Materials and methods: Tumor tissues from 158 Korean patients diagnosed with SCLC from September 2009 to February 2013 were collected and analyzed using an FGFR1 FISH assay with a probe that hybridized to chromosome region 8p12-8p11.23 (Abbott Molecular, Abbott Park, IL). Results and conclusion: FGFR1 amplification was detected in three patients (1.9%) harboring extensive disease (ED). A multivariate analysis showed that among the patients with ED, FGFR1 amplification was associated with shorter disease-free survival to first-line chemotherapy with etoposide plus cisplatin or carboplatin (hazard ratio [HR] = 7.1; 95% confidence interval [CI] = 2.0-25.4; P = 0.003). The median overall survival time of the patients with ED was 8.2 and 10.2 months among patients with and without FGFR1 amplification, respectively (P = 0.37). Although FGFR1 amplification is rare in SCLC compared to non-small cell lung cancer or other malignancies with squamous histology, it is associated with poor survival following standard chemotherapy in SCLC. Further studies in large cohorts of patients with SCLC are needed to verify these results. Our results imply that FGFR1 may be a potential therapeutic target in SCLC and it could be confirmed in a clinical trial.",

author = "Park, {Ji Soo} and Lee, {Jae Seok} and Kim, {Eun Young} and Jung, {Ji Ye} and Kim, {Se Kyu} and Joon Chang and Kim, {Dae Joon} and Lee, {Chang Young} and Inkyung Jung and Kim, {Joo Hang} and Kim, {Hye Ryun} and Moon, {Yong Wha} and Kim, {Hyo Song} and Cho, {Byoung Chul} and Shim, {Hyo Sup}",

note = "Funding Information: This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( HI12C1440 , B.C. Cho), and a faculty research grant of Yonsei University College of Medicine for 2012 and 2013 ( 6-2012-0043 ; 6-2013-0016 to H.S. Shim). Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",

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doi = "10.1016/j.lungcan.2015.03.002",

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T1 - The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer

AU - Park, Ji Soo

AU - Lee, Jae Seok

AU - Kim, Eun Young

AU - Jung, Ji Ye

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Kim, Dae Joon

AU - Lee, Chang Young

AU - Jung, Inkyung

AU - Kim, Joo Hang

AU - Kim, Hye Ryun

AU - Moon, Yong Wha

AU - Kim, Hyo Song

AU - Cho, Byoung Chul

AU - Shim, Hyo Sup

N1 - Funding Information: This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( HI12C1440 , B.C. Cho), and a faculty research grant of Yonsei University College of Medicine for 2012 and 2013 ( 6-2012-0043 ; 6-2013-0016 to H.S. Shim). Publisher Copyright: © 2015 Elsevier Ireland Ltd.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objectives: Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in many human cancers. We tried to identify the frequency of FGFR1 amplifications among Korean patients with small cell lung cancer (SCLC). Additionally, we examined the clinical significance of FGFR1 amplifications for overall survival (OS) and progression-free survival (PFS) among SCLC patients who received standard chemotherapies. Materials and methods: Tumor tissues from 158 Korean patients diagnosed with SCLC from September 2009 to February 2013 were collected and analyzed using an FGFR1 FISH assay with a probe that hybridized to chromosome region 8p12-8p11.23 (Abbott Molecular, Abbott Park, IL). Results and conclusion: FGFR1 amplification was detected in three patients (1.9%) harboring extensive disease (ED). A multivariate analysis showed that among the patients with ED, FGFR1 amplification was associated with shorter disease-free survival to first-line chemotherapy with etoposide plus cisplatin or carboplatin (hazard ratio [HR] = 7.1; 95% confidence interval [CI] = 2.0-25.4; P = 0.003). The median overall survival time of the patients with ED was 8.2 and 10.2 months among patients with and without FGFR1 amplification, respectively (P = 0.37). Although FGFR1 amplification is rare in SCLC compared to non-small cell lung cancer or other malignancies with squamous histology, it is associated with poor survival following standard chemotherapy in SCLC. Further studies in large cohorts of patients with SCLC are needed to verify these results. Our results imply that FGFR1 may be a potential therapeutic target in SCLC and it could be confirmed in a clinical trial.

AB - Objectives: Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in many human cancers. We tried to identify the frequency of FGFR1 amplifications among Korean patients with small cell lung cancer (SCLC). Additionally, we examined the clinical significance of FGFR1 amplifications for overall survival (OS) and progression-free survival (PFS) among SCLC patients who received standard chemotherapies. Materials and methods: Tumor tissues from 158 Korean patients diagnosed with SCLC from September 2009 to February 2013 were collected and analyzed using an FGFR1 FISH assay with a probe that hybridized to chromosome region 8p12-8p11.23 (Abbott Molecular, Abbott Park, IL). Results and conclusion: FGFR1 amplification was detected in three patients (1.9%) harboring extensive disease (ED). A multivariate analysis showed that among the patients with ED, FGFR1 amplification was associated with shorter disease-free survival to first-line chemotherapy with etoposide plus cisplatin or carboplatin (hazard ratio [HR] = 7.1; 95% confidence interval [CI] = 2.0-25.4; P = 0.003). The median overall survival time of the patients with ED was 8.2 and 10.2 months among patients with and without FGFR1 amplification, respectively (P = 0.37). Although FGFR1 amplification is rare in SCLC compared to non-small cell lung cancer or other malignancies with squamous histology, it is associated with poor survival following standard chemotherapy in SCLC. Further studies in large cohorts of patients with SCLC are needed to verify these results. Our results imply that FGFR1 may be a potential therapeutic target in SCLC and it could be confirmed in a clinical trial.

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The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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