TY - JOUR
T1 - The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis
T2 - A randomised controlled study
AU - Kim, S. Y.
AU - Koo, B. N.
AU - Shin, C. S.
AU - Ban, M.
AU - Han, K.
AU - Kim, M. D.
N1 - Publisher Copyright:
© 2015 Royal College of Obstetricians and Gynaecologists.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). Design Prospective, randomised, double-blind, and placebo-controlled study. Setting Tertiary-care University centre in Korea. Population Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. Methods Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. Main outcome measures The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. Results Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. Conclusions The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.
AB - Objective To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). Design Prospective, randomised, double-blind, and placebo-controlled study. Setting Tertiary-care University centre in Korea. Population Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. Methods Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. Main outcome measures The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. Results Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. Conclusions The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation. Tweetable abstract Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.
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U2 - 10.1111/1471-0528.13785
DO - 10.1111/1471-0528.13785
M3 - Article
C2 - 26667403
AN - SCOPUS:84959551580
SN - 1470-0328
VL - 123
SP - 580
EP - 587
JO - The Journal of obstetrics and gynaecology of the British Empire
JF - The Journal of obstetrics and gynaecology of the British Empire
IS - 4
ER -