The effects of non-thermal atmospheric pressure plasma jet on cellular activity at SLA-treated titanium surfaces

Eun Jung Lee, Jae Sung Kwon, Soo Hyuk Uhm, Doo Hoon Song, Yong Hee Kim, Eun Ha Choi, Kyoung Nam Kim

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31 Citations (Scopus)


Titanium (Ti) is a primary material used for dental implants, and the sandblasted, large-grit, and acid-etched (SLA) surface treatment is commonly used on titanium to promote early osseointegration. Despite their benefits, SLA-treated Ti surfaces are disadvantaged by their hydrophobic property, and much research has been performed to address this problem. In current study, we hypothesized the effects of a nitrogen-based non-thermal atmospheric pressure plasma jet (NTAPPJ) treatment on SLA-treated Ti would increase hydrophilicity and cellular activity. Samples with and without the NTAPPJ treatment were analyzed using a field emission scanning electron microscope, optical surface roughness system, X-ray photoelectron spectroscope, and water contact angle measuring system. MC3T3-E1 cells (murine osteoblastic cell line) attachments and proliferations were examined by the MTT and BrdU colorimetry assay. Cell immunofluorescent microscopic images were observed by a confocal laser scanning microscope for a morphological analysis. This study found that the nitrogen-based NTAPPJ treatment on SLA-treated Ti significantly increased the hydrophilicity and MC3T3-E1 cell attachments and proliferations. Hence, it was concluded that an additional procedure of nitrogen-based NTAPPJ treatment just prior to implantation of SLA-treated Ti into oral defect sites could improve the success of dental implant surgery.

Original languageEnglish
Pages (from-to)S36-S41
JournalCurrent Applied Physics
Issue numberSUPPL.1
Publication statusPublished - 2013 Mar 20

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program and the SRC program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2012R1A1A2008659 and 20100029418 , respectively).

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physics and Astronomy(all)


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