The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects

Jung Yoo Choi, Ui Won Jung, Chang Sung Kim, Tae Kwan Eom, Eun Jung Kang, Kyoo Sung Cho, Chong Kwan Kim, Seong Ho Choi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Purpose: Significant interest has emerged in the design of cell scaffolds that incorporate peptide sequences that correspond to known signaling domains in extracellular matrix and bone morphogenetic protein. The purpose of this study was to evalu- ate the bone regenerative effects of the synthetic peptide in a critical-size rat calvarial defect model. Methods: Eight millimeter diameter standardized, circular, transosseus defects created on the cranium of forty rats were im- planted with synthetic peptide, collagen, or both synthetic peptide and collagen. No material was was implanted the control group. The healing of each group was evaluated histologically and histomorphometrically after 2- and 8-week healing inter- vals. Results: Surgical implantation of the synthetic peptide and collagen resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. When the experimental groups were compared to each other, they showed a similar pattern of bone formation. The defect closure and new bone area were significantly different in synthetic peptide and collagen group at 8 weeks. Conclusions: Concerning the advantages of biomaterials, synthetic peptide can be an effective biomaterial for damaged periodontal regeneration.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalJournal of Periodontal and Implant Science
Issue number1
Publication statusPublished - 2010 Feb 28

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics


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