The effects of multi-growth factors-containing cream on post-Thyroidectomy scars: A preliminary study

Sungsik Shin, Jung U. Shin, Youngin Lee, Woong Youn Chung, Kee Hyun Nam, Tae Gwang Kwon, Ju Hee Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Growth factors play important roles in wound healing. However, the evidence for the effects of growth factors on post-Thyroidectomy scars is limited. Objective: We performed a prospective study to assess the preventive and therapeutic effect of a multi-growth factor (MGF)-containing cream on post-Thyroidectomy scars. Methods: Twenty-one patients with thyroidectomy scars applied MGF cream twice a day. We assessed the changes in erythema, pigmentation, skin elasticity, and skin hydration status using the erythema index, melanin index, cutometer, and corneometer, respectively. In addition, Vancouver scar scale (VSS) and patient satisfaction were assessed at 10 days after surgery (baseline), 2 weeks, 6 weeks, and 12 weeks after baseline. Results: The mean total VSS scores were significantly lower at 6 weeks (3.24±1.51 vs. 1.91±1.38) and 12 weeks (3.24±1.51 vs. 1.71±1.59) compared to the baseline. The degree of pigmentation was significantly lower at 12 weeks compared to the baseline, and the skin elasticity, and the skin hydration status were significantly higher at 12 weeks compared to the baseline. Over 85% of the patients were satisfied with the use of MGF cream without any adverse effect. Conclusion: MGF cream might have additive or supportive effect for scar formation after thyroidectomy.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalAnnals of Dermatology
Issue number3
Publication statusPublished - 2017 Jun

Bibliographical note

Publisher Copyright:
Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology.

All Science Journal Classification (ASJC) codes

  • Dermatology


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