TY - JOUR
T1 - The effect of moesin overexpression on ageing of human dermal microvascular endothelial cells
AU - Lee, Ju Hee
AU - Hong, In Ae
AU - Oh, Sang Ho
AU - Kwon, Yeon Sook
AU - Cho, Soo Hyun
AU - Lee, Kwang Hoon
PY - 2009/11
Y1 - 2009/11
N2 - Senescence of microvascular endothelial cells is known to play an important role in the pathophysiology of vascular diseases related to ageing, but the accurate mechanism or related genes are not known. Moesin, a cytoskeletal protein and the most potent candidate as an ageing-related protein, showed obvious changes in expression when compared before and after ageing. In this study, a lentivirus was used to overexpress moesin in endothelial cells. The expression of cell cycle mediators such as p16, cyclin D1 and cdk4, which can be the markers of ageing, was compared by RNA and was shown to be suppressed in moesin overexpressed endothelial cells. In conclusion, it can be said that the expression of moesin delays senescence of human dermal microvascular endothelial cells and this fundamental discovery can be used as a basis for understanding the mechanism of ageing and age-related diseases.
AB - Senescence of microvascular endothelial cells is known to play an important role in the pathophysiology of vascular diseases related to ageing, but the accurate mechanism or related genes are not known. Moesin, a cytoskeletal protein and the most potent candidate as an ageing-related protein, showed obvious changes in expression when compared before and after ageing. In this study, a lentivirus was used to overexpress moesin in endothelial cells. The expression of cell cycle mediators such as p16, cyclin D1 and cdk4, which can be the markers of ageing, was compared by RNA and was shown to be suppressed in moesin overexpressed endothelial cells. In conclusion, it can be said that the expression of moesin delays senescence of human dermal microvascular endothelial cells and this fundamental discovery can be used as a basis for understanding the mechanism of ageing and age-related diseases.
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U2 - 10.1111/j.1600-0625.2009.00898.x
DO - 10.1111/j.1600-0625.2009.00898.x
M3 - Letter
C2 - 19555429
AN - SCOPUS:70350783816
SN - 0906-6705
VL - 18
SP - 997
EP - 999
JO - Experimental dermatology
JF - Experimental dermatology
IS - 11
ER -
