The clinical significance of a positive Amnisure test™ in women with term labor with intact membranes

Seung Mi Lee; Joonho Lee; Hyo Suk Seong; Si Eun Lee; Joong Shin Park; Roberto Romero; Bo Hyun Yoon

doi:10.1080/14767050902801694

The clinical significance of a positive Amnisure test™ in women with term labor with intact membranes

Seung Mi Lee, Joonho Lee, Hyo Suk Seong, Si Eun Lee, Joong Shin Park, Roberto Romero, Bo Hyun Yoon

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Objective.The Amnisure ROM™ test is approved for the diagnosis of rupture of membranes ROM. Yet, a fraction of patients with a positive test have intact membranes by sterile speculum examination. The objective of this study was to determine the clinical significance of this finding. Methods.The study population consisted of four groups of nulliparous women at term: 1 not in labor without clinical evidence of ROM n 125; 2 in labor without clinical ROM with a negative Amnisure test™ n 56; 3 in labor without clinical ROM with a positive Amnisure test™ n 25; and 4 in labor with clinical ROM n 30. The Amnisure test™ was performed in cases without clinical ROM Groups 1, 2 and 3. Results.1 The Amnisure test™ was positive more frequently in women in labor with intact membranes than in patients not in labor at term without ROM 30.9 2581 women vs. 4.8 6125 women; p < 0.001; 2 patients in labor without clinical ROM with a positive Amnisure test™ had a significantly shorter admission-to-delivery interval than those in labor without clinical ROM with a negative Amnisure test™ p < 0.05. Conclusion.1 A positive Amnisure test™ is present in about one-third nulliparous women at term presenting in labor with intact membranes; 2 patients with a positive Amnisure test™ had a shorter admission-to-delivery interval than those with a negative test.

Original language	English
Pages (from-to)	305-310
Number of pages	6
Journal	Journal of Maternal-Fetal and Neonatal Medicine
Volume	22
Issue number	4
DOIs	https://doi.org/10.1080/14767050902801694
Publication status	Published - 2009

Bibliographical note

Funding Information:
This research was supported in part by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS. The Amnisure ROM testTM (the placental a-microglobulin-1 immunoassay) kits were provided free of charge by the Korean supplier of N-Dia Inc. (New York, NY). N-Dia Inc. did not contribute funds towards this study. None of the authors own any stock in this company and are either current or former employees of this company or are members of a speaker’s bureau for this company.

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

Access to Document

10.1080/14767050902801694

Cite this

@article{1e6b934046a548198bedc8868254f571,

title = "The clinical significance of a positive Amnisure test{\texttrademark} in women with term labor with intact membranes",

abstract = "Objective.The Amnisure ROM{\texttrademark} test is approved for the diagnosis of rupture of membranes ROM. Yet, a fraction of patients with a positive test have intact membranes by sterile speculum examination. The objective of this study was to determine the clinical significance of this finding. Methods.The study population consisted of four groups of nulliparous women at term: 1 not in labor without clinical evidence of ROM n 125; 2 in labor without clinical ROM with a negative Amnisure test{\texttrademark} n 56; 3 in labor without clinical ROM with a positive Amnisure test{\texttrademark} n 25; and 4 in labor with clinical ROM n 30. The Amnisure test{\texttrademark} was performed in cases without clinical ROM Groups 1, 2 and 3. Results.1 The Amnisure test{\texttrademark} was positive more frequently in women in labor with intact membranes than in patients not in labor at term without ROM 30.9 2581 women vs. 4.8 6125 women; p < 0.001; 2 patients in labor without clinical ROM with a positive Amnisure test{\texttrademark} had a significantly shorter admission-to-delivery interval than those in labor without clinical ROM with a negative Amnisure test{\texttrademark} p < 0.05. Conclusion.1 A positive Amnisure test{\texttrademark} is present in about one-third nulliparous women at term presenting in labor with intact membranes; 2 patients with a positive Amnisure test{\texttrademark} had a shorter admission-to-delivery interval than those with a negative test.",

author = "Lee, {Seung Mi} and Joonho Lee and Seong, {Hyo Suk} and Lee, {Si Eun} and Park, {Joong Shin} and Roberto Romero and Yoon, {Bo Hyun}",

note = "Funding Information: This research was supported in part by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS. The Amnisure ROM testTM (the placental a-microglobulin-1 immunoassay) kits were provided free of charge by the Korean supplier of N-Dia Inc. (New York, NY). N-Dia Inc. did not contribute funds towards this study. None of the authors own any stock in this company and are either current or former employees of this company or are members of a speaker{\textquoteright}s bureau for this company.",

year = "2009",

doi = "10.1080/14767050902801694",

language = "English",

volume = "22",

pages = "305--310",

journal = "Journal of Maternal-Fetal and Neonatal Medicine",

issn = "1476-7058",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - The clinical significance of a positive Amnisure test™ in women with term labor with intact membranes

AU - Lee, Seung Mi

AU - Lee, Joonho

AU - Seong, Hyo Suk

AU - Lee, Si Eun

AU - Park, Joong Shin

AU - Romero, Roberto

AU - Yoon, Bo Hyun

N1 - Funding Information: This research was supported in part by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS. The Amnisure ROM testTM (the placental a-microglobulin-1 immunoassay) kits were provided free of charge by the Korean supplier of N-Dia Inc. (New York, NY). N-Dia Inc. did not contribute funds towards this study. None of the authors own any stock in this company and are either current or former employees of this company or are members of a speaker’s bureau for this company.

PY - 2009

Y1 - 2009

N2 - Objective.The Amnisure ROM™ test is approved for the diagnosis of rupture of membranes ROM. Yet, a fraction of patients with a positive test have intact membranes by sterile speculum examination. The objective of this study was to determine the clinical significance of this finding. Methods.The study population consisted of four groups of nulliparous women at term: 1 not in labor without clinical evidence of ROM n 125; 2 in labor without clinical ROM with a negative Amnisure test™ n 56; 3 in labor without clinical ROM with a positive Amnisure test™ n 25; and 4 in labor with clinical ROM n 30. The Amnisure test™ was performed in cases without clinical ROM Groups 1, 2 and 3. Results.1 The Amnisure test™ was positive more frequently in women in labor with intact membranes than in patients not in labor at term without ROM 30.9 2581 women vs. 4.8 6125 women; p < 0.001; 2 patients in labor without clinical ROM with a positive Amnisure test™ had a significantly shorter admission-to-delivery interval than those in labor without clinical ROM with a negative Amnisure test™ p < 0.05. Conclusion.1 A positive Amnisure test™ is present in about one-third nulliparous women at term presenting in labor with intact membranes; 2 patients with a positive Amnisure test™ had a shorter admission-to-delivery interval than those with a negative test.

AB - Objective.The Amnisure ROM™ test is approved for the diagnosis of rupture of membranes ROM. Yet, a fraction of patients with a positive test have intact membranes by sterile speculum examination. The objective of this study was to determine the clinical significance of this finding. Methods.The study population consisted of four groups of nulliparous women at term: 1 not in labor without clinical evidence of ROM n 125; 2 in labor without clinical ROM with a negative Amnisure test™ n 56; 3 in labor without clinical ROM with a positive Amnisure test™ n 25; and 4 in labor with clinical ROM n 30. The Amnisure test™ was performed in cases without clinical ROM Groups 1, 2 and 3. Results.1 The Amnisure test™ was positive more frequently in women in labor with intact membranes than in patients not in labor at term without ROM 30.9 2581 women vs. 4.8 6125 women; p < 0.001; 2 patients in labor without clinical ROM with a positive Amnisure test™ had a significantly shorter admission-to-delivery interval than those in labor without clinical ROM with a negative Amnisure test™ p < 0.05. Conclusion.1 A positive Amnisure test™ is present in about one-third nulliparous women at term presenting in labor with intact membranes; 2 patients with a positive Amnisure test™ had a shorter admission-to-delivery interval than those with a negative test.

UR - http://www.scopus.com/inward/record.url?scp=67651042771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651042771&partnerID=8YFLogxK

U2 - 10.1080/14767050902801694

DO - 10.1080/14767050902801694

M3 - Article

C2 - 19350444

AN - SCOPUS:67651042771

SN - 1476-7058

VL - 22

SP - 305

EP - 310

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

IS - 4

ER -

The clinical significance of a positive Amnisure test™ in women with term labor with intact membranes

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this